Cargando…

Effect of Saraswatarishta in animal models of behavior despair

BACKGROUND: Saraswatarishta (SA) is a herbo-mineral formulation consisting of 18 plants some of which are Medhyarasayanas. It has been claimed to be useful in treating central nervous system disorders. OBJECTIVE: To evaluate antidepressant effect of ‘Saraswatarishta’(SA) alone and in combination wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Parekar, Reshma R., Jadhav, Kshitij S., Marathe, Padmaja A., Rege, Nirmala N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204283/
https://www.ncbi.nlm.nih.gov/pubmed/25336844
http://dx.doi.org/10.4103/0975-9476.140469
_version_ 1782340536558944256
author Parekar, Reshma R.
Jadhav, Kshitij S.
Marathe, Padmaja A.
Rege, Nirmala N.
author_facet Parekar, Reshma R.
Jadhav, Kshitij S.
Marathe, Padmaja A.
Rege, Nirmala N.
author_sort Parekar, Reshma R.
collection PubMed
description BACKGROUND: Saraswatarishta (SA) is a herbo-mineral formulation consisting of 18 plants some of which are Medhyarasayanas. It has been claimed to be useful in treating central nervous system disorders. OBJECTIVE: To evaluate antidepressant effect of ‘Saraswatarishta’(SA) alone and in combination with imipramine and fluoxetine in animal models of depression. MATERIALS AND METHODS: After obtaining IAEC permission, 144 rats (n = 36/part) were randomized into 6 groups- Group 1: Distilled water (1 mL), Group 2: Imipramine (30 mg/kg), Group 3: Fluoxetine (10 mg/kg), Group 4: SA (1.8 mL/kg), Group 5: Imipramine + SA, Group 6: Fluoxetine + SA. Effects of study drugs were evaluated in forced swim test (FST) with single exposure to FST (Part 1) and repeated exposure for 14 days (Part 2). In Part 3, reserpine was used with FST and effects of study drugs were evaluated against single exposure to FST. Same model was used with repeated exposures to FST (Part 4). In each part, rats were subjected to open field test (OFT) for 5 min prior to final FST. The variables measured: Immobility time in FST; line crossing, rearing and defecation in the OFT. RESULTS: In all four parts, individual drugs and combinations thereof produced significant decrease in immobility time as compared to control, and extent of decrease was comparable amongst these groups. However, values for combination of fluoxetine with SA group were found to be lesser than that for individual agents in Parts 2 and 3. Combination of SA with imipramine did not enhance its anti-depressant effect in any of the parts. OFT findings did not vary significantly amongst the study groups. CONCLUSION: Decreased immobility in FST and absence of generalized stimulation or depression of motor activity in OFT point towards potential antidepressant effect of Saraswatarishta. Its co-administration with fluoxetine showed more promising effects.
format Online
Article
Text
id pubmed-4204283
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-42042832014-10-21 Effect of Saraswatarishta in animal models of behavior despair Parekar, Reshma R. Jadhav, Kshitij S. Marathe, Padmaja A. Rege, Nirmala N. J Ayurveda Integr Med Original Research Article BACKGROUND: Saraswatarishta (SA) is a herbo-mineral formulation consisting of 18 plants some of which are Medhyarasayanas. It has been claimed to be useful in treating central nervous system disorders. OBJECTIVE: To evaluate antidepressant effect of ‘Saraswatarishta’(SA) alone and in combination with imipramine and fluoxetine in animal models of depression. MATERIALS AND METHODS: After obtaining IAEC permission, 144 rats (n = 36/part) were randomized into 6 groups- Group 1: Distilled water (1 mL), Group 2: Imipramine (30 mg/kg), Group 3: Fluoxetine (10 mg/kg), Group 4: SA (1.8 mL/kg), Group 5: Imipramine + SA, Group 6: Fluoxetine + SA. Effects of study drugs were evaluated in forced swim test (FST) with single exposure to FST (Part 1) and repeated exposure for 14 days (Part 2). In Part 3, reserpine was used with FST and effects of study drugs were evaluated against single exposure to FST. Same model was used with repeated exposures to FST (Part 4). In each part, rats were subjected to open field test (OFT) for 5 min prior to final FST. The variables measured: Immobility time in FST; line crossing, rearing and defecation in the OFT. RESULTS: In all four parts, individual drugs and combinations thereof produced significant decrease in immobility time as compared to control, and extent of decrease was comparable amongst these groups. However, values for combination of fluoxetine with SA group were found to be lesser than that for individual agents in Parts 2 and 3. Combination of SA with imipramine did not enhance its anti-depressant effect in any of the parts. OFT findings did not vary significantly amongst the study groups. CONCLUSION: Decreased immobility in FST and absence of generalized stimulation or depression of motor activity in OFT point towards potential antidepressant effect of Saraswatarishta. Its co-administration with fluoxetine showed more promising effects. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4204283/ /pubmed/25336844 http://dx.doi.org/10.4103/0975-9476.140469 Text en Copyright: © Journal of Ayurveda and Integrative Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Parekar, Reshma R.
Jadhav, Kshitij S.
Marathe, Padmaja A.
Rege, Nirmala N.
Effect of Saraswatarishta in animal models of behavior despair
title Effect of Saraswatarishta in animal models of behavior despair
title_full Effect of Saraswatarishta in animal models of behavior despair
title_fullStr Effect of Saraswatarishta in animal models of behavior despair
title_full_unstemmed Effect of Saraswatarishta in animal models of behavior despair
title_short Effect of Saraswatarishta in animal models of behavior despair
title_sort effect of saraswatarishta in animal models of behavior despair
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204283/
https://www.ncbi.nlm.nih.gov/pubmed/25336844
http://dx.doi.org/10.4103/0975-9476.140469
work_keys_str_mv AT parekarreshmar effectofsaraswatarishtainanimalmodelsofbehaviordespair
AT jadhavkshitijs effectofsaraswatarishtainanimalmodelsofbehaviordespair
AT marathepadmajaa effectofsaraswatarishtainanimalmodelsofbehaviordespair
AT regenirmalan effectofsaraswatarishtainanimalmodelsofbehaviordespair