Kinetic Analysis of Human PrimPol DNA Polymerase Activity Reveals a Generally Error-Prone Enzyme Capable of Accurately Bypassing 7,8-Dihydro-8-oxo-2′-deoxyguanosine

[Image: see text] Recent studies have identified human PrimPol as a new RNA/DNA primase and translesion DNA synthesis polymerase (TLS pol) that contributes to nuclear and mitochondrial DNA replication. We investigated the mechanism of PrimPol polymerase activity on both undamaged and damaged DNA sub...

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Detalles Bibliográficos
Autores principales: Zafar, Maroof K., Ketkar, Amit, Lodeiro, Maria F., Cameron, Craig E., Eoff, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204878/
https://www.ncbi.nlm.nih.gov/pubmed/25255211
http://dx.doi.org/10.1021/bi501024u

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204878/
https://www.ncbi.nlm.nih.gov/pubmed/25255211
http://dx.doi.org/10.1021/bi501024u

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