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Polycomb Repressive Complex 2 Regulates Lineage Fidelity during Embryonic Stem Cell Differentiation

Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failu...

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Detalles Bibliográficos
Autores principales:	Thornton, Seraphim R., Butty, Vincent L., Levine, Stuart S., Boyer, Laurie A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204901/ https://www.ncbi.nlm.nih.gov/pubmed/25333635 http://dx.doi.org/10.1371/journal.pone.0110498

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