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Rapid Plasticity in the Prefrontal Cortex during Affective Associative Learning

MultiCS conditioning is an affective associative learning paradigm, in which affective categories consist of many similar and complex stimuli. Comparing visual processing before and after learning, recent MultiCS conditioning studies using time-sensitive magnetoencephalography (MEG) revealed enhance...

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Autores principales: Rehbein, Maimu A., Steinberg, Christian, Wessing, Ida, Pastor, María Carmen, Zwitserlood, Pienie, Keuper, Kati, Junghöfer, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204938/
https://www.ncbi.nlm.nih.gov/pubmed/25333631
http://dx.doi.org/10.1371/journal.pone.0110720
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author Rehbein, Maimu A.
Steinberg, Christian
Wessing, Ida
Pastor, María Carmen
Zwitserlood, Pienie
Keuper, Kati
Junghöfer, Markus
author_facet Rehbein, Maimu A.
Steinberg, Christian
Wessing, Ida
Pastor, María Carmen
Zwitserlood, Pienie
Keuper, Kati
Junghöfer, Markus
author_sort Rehbein, Maimu A.
collection PubMed
description MultiCS conditioning is an affective associative learning paradigm, in which affective categories consist of many similar and complex stimuli. Comparing visual processing before and after learning, recent MultiCS conditioning studies using time-sensitive magnetoencephalography (MEG) revealed enhanced activation of prefrontal cortex (PFC) regions towards emotionally paired versus neutral stimuli already during short-latency processing stages (i.e., 50 to 80 ms after stimulus onset). The present study aimed at showing that this rapid differential activation develops as a function of the acquisition and not the extinction of the emotional meaning associated with affectively paired stimuli. MEG data of a MultiCS conditioning study were analyzed with respect to rapid changes in PFC activation towards aversively (electric shock) paired and unpaired faces that occurred during the learning of stimulus-reinforcer contingencies. Analyses revealed an increased PFC activation towards paired stimuli during 50 to 80 ms already during the acquisition of contingencies, which emerged after a single pairing with the electric shock. Corresponding changes in stimulus valence could be observed in ratings of hedonic valence, although participants did not seem to be aware of contingencies. These results suggest rapid formation and access of emotional stimulus meaning in the PFC as well as a great capacity for adaptive and highly resolving learning in the brain under challenging circumstances.
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spelling pubmed-42049382014-10-27 Rapid Plasticity in the Prefrontal Cortex during Affective Associative Learning Rehbein, Maimu A. Steinberg, Christian Wessing, Ida Pastor, María Carmen Zwitserlood, Pienie Keuper, Kati Junghöfer, Markus PLoS One Research Article MultiCS conditioning is an affective associative learning paradigm, in which affective categories consist of many similar and complex stimuli. Comparing visual processing before and after learning, recent MultiCS conditioning studies using time-sensitive magnetoencephalography (MEG) revealed enhanced activation of prefrontal cortex (PFC) regions towards emotionally paired versus neutral stimuli already during short-latency processing stages (i.e., 50 to 80 ms after stimulus onset). The present study aimed at showing that this rapid differential activation develops as a function of the acquisition and not the extinction of the emotional meaning associated with affectively paired stimuli. MEG data of a MultiCS conditioning study were analyzed with respect to rapid changes in PFC activation towards aversively (electric shock) paired and unpaired faces that occurred during the learning of stimulus-reinforcer contingencies. Analyses revealed an increased PFC activation towards paired stimuli during 50 to 80 ms already during the acquisition of contingencies, which emerged after a single pairing with the electric shock. Corresponding changes in stimulus valence could be observed in ratings of hedonic valence, although participants did not seem to be aware of contingencies. These results suggest rapid formation and access of emotional stimulus meaning in the PFC as well as a great capacity for adaptive and highly resolving learning in the brain under challenging circumstances. Public Library of Science 2014-10-21 /pmc/articles/PMC4204938/ /pubmed/25333631 http://dx.doi.org/10.1371/journal.pone.0110720 Text en © 2014 Rehbein et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Rehbein, Maimu A.
Steinberg, Christian
Wessing, Ida
Pastor, María Carmen
Zwitserlood, Pienie
Keuper, Kati
Junghöfer, Markus
Rapid Plasticity in the Prefrontal Cortex during Affective Associative Learning
title Rapid Plasticity in the Prefrontal Cortex during Affective Associative Learning
title_full Rapid Plasticity in the Prefrontal Cortex during Affective Associative Learning
title_fullStr Rapid Plasticity in the Prefrontal Cortex during Affective Associative Learning
title_full_unstemmed Rapid Plasticity in the Prefrontal Cortex during Affective Associative Learning
title_short Rapid Plasticity in the Prefrontal Cortex during Affective Associative Learning
title_sort rapid plasticity in the prefrontal cortex during affective associative learning
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204938/
https://www.ncbi.nlm.nih.gov/pubmed/25333631
http://dx.doi.org/10.1371/journal.pone.0110720
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