Whole cells in enantioselective reduction of benzyl acetoacetate

The β-ketoester benzyl acetoacetate was enantioselectively reduced to benzyl (S)-3-hydroxybutanoate by seven microorganism species. The best result using free cells was obtained with the yeast Hansenula sp., which furnished 97% ee and 85% of conversion within 24 h. After immobilization in calcium al...

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Detalles Bibliográficos
Autores principales: Ribeiro, Joyce Benzaquem, Ramos, Aline de Souza, Lopes, Raquel de Oliveira, da Silva, Gabriela Veloso Vieira, de Souza, Rodrigo Octavio Mendonça Alves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204978/
https://www.ncbi.nlm.nih.gov/pubmed/25477927
Descripción
Sumario:The β-ketoester benzyl acetoacetate was enantioselectively reduced to benzyl (S)-3-hydroxybutanoate by seven microorganism species. The best result using free cells was obtained with the yeast Hansenula sp., which furnished 97% ee and 85% of conversion within 24 h. After immobilization in calcium alginate spheres, K.marxianus showed to be more stable after 2 cycles of reaction.

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