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Protein–Polymer Conjugation via Ligand Affinity and Photoactivation of Glutathione S-Transferase
[Image: see text] A photoactivated, site-selective conjugation of poly(ethylene glycol) (PEG) to the glutathione (GSH) binding pocket of glutathione S-transferase (GST) is described. To achieve this, a GSH analogue (GSH-BP) was designed and chemically synthesized with three functionalities: (1) the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205000/ https://www.ncbi.nlm.nih.gov/pubmed/25315970 http://dx.doi.org/10.1021/bc500380r |