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Mutation study of DsrM from Allochromatium vinosum using the amino acid sequences()

Sulfur metabolism is one of the oldest known environmental processes. The operon involved in this process is called the dsr operon. The vital role of the operon is to maintain the environmental sulfur balance. The dsr operon of proteobacteria consists of 15 genes, viz. dsrABEFHCMKLJOPNRS. The protei...

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Detalles Bibliográficos
Autores principales: Ghosh, Semanti, Bagchi, Angshuman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205035/
https://www.ncbi.nlm.nih.gov/pubmed/25606372
http://dx.doi.org/10.1016/j.mgene.2013.10.006
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author Ghosh, Semanti
Bagchi, Angshuman
author_facet Ghosh, Semanti
Bagchi, Angshuman
author_sort Ghosh, Semanti
collection PubMed
description Sulfur metabolism is one of the oldest known environmental processes. The operon involved in this process is called the dsr operon. The vital role of the operon is to maintain the environmental sulfur balance. The dsr operon of proteobacteria consists of 15 genes, viz. dsrABEFHCMKLJOPNRS. The proteins encoded by the dsr operon are essential for the transfer of sulfur globules from periplasm to cytosol and oxidation of the stored sulfur. In the present study we tried to analyze the probable molecular details of the DsrM proteins from a diverse set of microbial species using their sequence information. There are certain mutations in the sequences of the DsrM proteins from the different proteobacterial species. The effects of mutations in the sequences of DsrM proteins were predicted from the evolutionary point of view. This is so far the first report of its kind. Our study would therefore enable the researches to predict the hitherto unknown biochemistry of sulfur oxidation using the amino acid sequences of the DsrM proteins.
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spelling pubmed-42050352015-01-20 Mutation study of DsrM from Allochromatium vinosum using the amino acid sequences() Ghosh, Semanti Bagchi, Angshuman Meta Gene Article Sulfur metabolism is one of the oldest known environmental processes. The operon involved in this process is called the dsr operon. The vital role of the operon is to maintain the environmental sulfur balance. The dsr operon of proteobacteria consists of 15 genes, viz. dsrABEFHCMKLJOPNRS. The proteins encoded by the dsr operon are essential for the transfer of sulfur globules from periplasm to cytosol and oxidation of the stored sulfur. In the present study we tried to analyze the probable molecular details of the DsrM proteins from a diverse set of microbial species using their sequence information. There are certain mutations in the sequences of the DsrM proteins from the different proteobacterial species. The effects of mutations in the sequences of DsrM proteins were predicted from the evolutionary point of view. This is so far the first report of its kind. Our study would therefore enable the researches to predict the hitherto unknown biochemistry of sulfur oxidation using the amino acid sequences of the DsrM proteins. Elsevier 2013-11-10 /pmc/articles/PMC4205035/ /pubmed/25606372 http://dx.doi.org/10.1016/j.mgene.2013.10.006 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Ghosh, Semanti
Bagchi, Angshuman
Mutation study of DsrM from Allochromatium vinosum using the amino acid sequences()
title Mutation study of DsrM from Allochromatium vinosum using the amino acid sequences()
title_full Mutation study of DsrM from Allochromatium vinosum using the amino acid sequences()
title_fullStr Mutation study of DsrM from Allochromatium vinosum using the amino acid sequences()
title_full_unstemmed Mutation study of DsrM from Allochromatium vinosum using the amino acid sequences()
title_short Mutation study of DsrM from Allochromatium vinosum using the amino acid sequences()
title_sort mutation study of dsrm from allochromatium vinosum using the amino acid sequences()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205035/
https://www.ncbi.nlm.nih.gov/pubmed/25606372
http://dx.doi.org/10.1016/j.mgene.2013.10.006
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