Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis

Intestinal fibrostenosis is among the hallmarks of severe Crohn’s disease. Patients with certain TNFSF15 (gene name for TL1A) variants over-express TL1A and have a higher risk of developing strictures in the small intestine. Additionally, sustained Tl1a expression in mice leads to small and large in...

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Detalles Bibliográficos
Autores principales: Shih, David Q, Zheng, Libo, Zhang, Xiaolan, Zhang, Hong, Kanazawa, Yoshitake, Ichikawa, Ryan, Wallace, Kori L, Chen, Jeremy, Pothoulakis, Charalabos, Koon, Hon W, Targan, Stephan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205266/
https://www.ncbi.nlm.nih.gov/pubmed/24850426
http://dx.doi.org/10.1038/mi.2014.37

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