Cargando…
Triptolide inhibits human immunodeficiency virus type 1 replication by promoting proteasomal degradation of Tat protein
BACKGROUND: Plants remain an important source of new drugs, new leads and new chemical entities. Triptolide is a diterpenoid epoxide isolated from Tripterygium wilfordii Hook F that possesses a broad range of bioactivities, including anti-inflammatory, immunosuppressive and anti-tumor properties. Th...
Autores principales: | Wan, Zhitao, Chen, Xulin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205289/ https://www.ncbi.nlm.nih.gov/pubmed/25323821 http://dx.doi.org/10.1186/s12977-014-0088-6 |
Ejemplares similares
-
Fangchinoline Inhibits Human Immunodeficiency Virus Type 1 Replication by Interfering with gp160 Proteolytic Processing
por: Wan, Zhitao, et al.
Publicado: (2012) -
Curcumin inhibits HIV-1 by promoting Tat protein degradation
por: Ali, Amjad, et al.
Publicado: (2016) -
Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)
por: Wang, Ying, et al.
Publicado: (2011) -
Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein
por: Adolph, Ramona S., et al.
Publicado: (2023) -
Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication
por: Miller, Leia K, et al.
Publicado: (2013)