Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here we show that either ubiq...

Descripción completa

Detalles Bibliográficos
Autores principales: Keller, Johannes, Catala-Lehnen, Philip, Huebner, Antje K., Jeschke, Anke, Heckt, Timo, Lueth, Anja, Krause, Matthias, Koehne, Till, Albers, Joachim, Schulze, Jochen, Schilling, Sarah, Haberland, Michael, Denninger, Hannah, Neven, Mona, Hermans-Borgmeyer, Irm, Streichert, Thomas, Breer, Stefan, Barvencik, Florian, Levkau, Bodo, Rathkolb, Birgit, Wolf, Eckhard, Calzada-Wack, Julia, Neff, Frauke, Gailus-Durner, Valerie, Fuchs, Helmut, de Angelis, Martin Hrabĕ, Klutmann, Susanne, Tsourdi, Elena, Hofbauer, Lorenz C., Kleuser, Burkhard, Chun, Jerold, Schinke, Thorsten, Amling, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205484/
https://www.ncbi.nlm.nih.gov/pubmed/25333900
http://dx.doi.org/10.1038/ncomms6215

Ejemplares similares

Ejemplares similares