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Does Age at Onset of First Major Depressive Episode Indicate the Subtype of Major Depressive Disorder?: The Clinical Research Center for Depression Study

PURPOSE: The purpose of this study was to evaluate the effects of age at onset of the first major depressive episode on the clinical features of individuals with major depressive disorder (MDD) in a large cohort of Korean depressed patients. MATERIALS AND METHODS: We recruited 419 MDD patients of ag...

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Autores principales: Park, Seon-Cheol, Hahn, Sang-Woo, Hwang, Tae-Yeon, Kim, Jae-Min, Jun, Tae-Youn, Lee, Min-Soo, Kim, Jung-Bum, Yim, Hyeon-Woo, Park, Yong Chon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205714/
https://www.ncbi.nlm.nih.gov/pubmed/25323911
http://dx.doi.org/10.3349/ymj.2014.55.6.1712
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author Park, Seon-Cheol
Hahn, Sang-Woo
Hwang, Tae-Yeon
Kim, Jae-Min
Jun, Tae-Youn
Lee, Min-Soo
Kim, Jung-Bum
Yim, Hyeon-Woo
Park, Yong Chon
author_facet Park, Seon-Cheol
Hahn, Sang-Woo
Hwang, Tae-Yeon
Kim, Jae-Min
Jun, Tae-Youn
Lee, Min-Soo
Kim, Jung-Bum
Yim, Hyeon-Woo
Park, Yong Chon
author_sort Park, Seon-Cheol
collection PubMed
description PURPOSE: The purpose of this study was to evaluate the effects of age at onset of the first major depressive episode on the clinical features of individuals with major depressive disorder (MDD) in a large cohort of Korean depressed patients. MATERIALS AND METHODS: We recruited 419 MDD patients of age over 18 years from the Clinical Research Center for Depression study in South Korea. At the start of the study, the onset age of the first major depressive episode was self-reported by the subjects. The subjects were divided into four age-at-onset subgroups: childhood and adolescent onset (ages <18), early adult onset (ages 18-44), middle adult onset (ages 45-59), and late onset (ages 60+). Using analysis of covariance (ANCOVA) and ordinal logistic regression analysis with adjusting the effect of age, the relationships between clinical features and age at onset of MDD were evaluated. RESULTS: There was an apparent, but inconsistent correlation between clinical features and age at onset. Earlier onset MDD was significantly associated with higher proportion of female gender [adjusted odds ratio (AOR)=0.570, p=0.022], more previous suicide attempts (AOR=0.635, p=0.038), greater number of previous depressive episodes (F=3.475, p=0.016) and higher scores on the brief psychiatric rating scale (F=3.254, p=0.022), its negative symptom subscale (F=6.082, p<0.0001), and the alcohol use disorder identification test (F=7.061, p<0.0001). CONCLUSION: Early age at onset may increase the likelihood of distinguishable MDD subtype, and age at onset of the first major depressive episode is a promising clinical indicator for the clinical presentation, course, and outcome of MDD.
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spelling pubmed-42057142014-11-01 Does Age at Onset of First Major Depressive Episode Indicate the Subtype of Major Depressive Disorder?: The Clinical Research Center for Depression Study Park, Seon-Cheol Hahn, Sang-Woo Hwang, Tae-Yeon Kim, Jae-Min Jun, Tae-Youn Lee, Min-Soo Kim, Jung-Bum Yim, Hyeon-Woo Park, Yong Chon Yonsei Med J Original Article PURPOSE: The purpose of this study was to evaluate the effects of age at onset of the first major depressive episode on the clinical features of individuals with major depressive disorder (MDD) in a large cohort of Korean depressed patients. MATERIALS AND METHODS: We recruited 419 MDD patients of age over 18 years from the Clinical Research Center for Depression study in South Korea. At the start of the study, the onset age of the first major depressive episode was self-reported by the subjects. The subjects were divided into four age-at-onset subgroups: childhood and adolescent onset (ages <18), early adult onset (ages 18-44), middle adult onset (ages 45-59), and late onset (ages 60+). Using analysis of covariance (ANCOVA) and ordinal logistic regression analysis with adjusting the effect of age, the relationships between clinical features and age at onset of MDD were evaluated. RESULTS: There was an apparent, but inconsistent correlation between clinical features and age at onset. Earlier onset MDD was significantly associated with higher proportion of female gender [adjusted odds ratio (AOR)=0.570, p=0.022], more previous suicide attempts (AOR=0.635, p=0.038), greater number of previous depressive episodes (F=3.475, p=0.016) and higher scores on the brief psychiatric rating scale (F=3.254, p=0.022), its negative symptom subscale (F=6.082, p<0.0001), and the alcohol use disorder identification test (F=7.061, p<0.0001). CONCLUSION: Early age at onset may increase the likelihood of distinguishable MDD subtype, and age at onset of the first major depressive episode is a promising clinical indicator for the clinical presentation, course, and outcome of MDD. Yonsei University College of Medicine 2014-11-01 2014-10-08 /pmc/articles/PMC4205714/ /pubmed/25323911 http://dx.doi.org/10.3349/ymj.2014.55.6.1712 Text en © Copyright: Yonsei University College of Medicine 2014 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Seon-Cheol
Hahn, Sang-Woo
Hwang, Tae-Yeon
Kim, Jae-Min
Jun, Tae-Youn
Lee, Min-Soo
Kim, Jung-Bum
Yim, Hyeon-Woo
Park, Yong Chon
Does Age at Onset of First Major Depressive Episode Indicate the Subtype of Major Depressive Disorder?: The Clinical Research Center for Depression Study
title Does Age at Onset of First Major Depressive Episode Indicate the Subtype of Major Depressive Disorder?: The Clinical Research Center for Depression Study
title_full Does Age at Onset of First Major Depressive Episode Indicate the Subtype of Major Depressive Disorder?: The Clinical Research Center for Depression Study
title_fullStr Does Age at Onset of First Major Depressive Episode Indicate the Subtype of Major Depressive Disorder?: The Clinical Research Center for Depression Study
title_full_unstemmed Does Age at Onset of First Major Depressive Episode Indicate the Subtype of Major Depressive Disorder?: The Clinical Research Center for Depression Study
title_short Does Age at Onset of First Major Depressive Episode Indicate the Subtype of Major Depressive Disorder?: The Clinical Research Center for Depression Study
title_sort does age at onset of first major depressive episode indicate the subtype of major depressive disorder?: the clinical research center for depression study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205714/
https://www.ncbi.nlm.nih.gov/pubmed/25323911
http://dx.doi.org/10.3349/ymj.2014.55.6.1712
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