NAD(+) protects against EAE by regulating CD4(+) T-cell differentiation

CD4(+) T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD(+)) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4(+)IFNγ(+)IL-10(+) T...

Descripción completa

Detalles Bibliográficos
Autores principales: Tullius, Stefan G., Biefer, Hector Rodriguez Cetina, Li, Suyan, Trachtenberg, Alexander J., Edtinger, Karoline, Quante, Markus, Krenzien, Felix, Uehara, Hirofumi, Yang, Xiaoyong, Kissick, Haydn T., Kuo, Winston P., Ghiran, Ionita, de la Fuente, Miguel A., Arredouani, Mohamed S., Camacho, Virginia, Tigges, John C., Toxavidis, Vasilis, El Fatimy, Rachid, Smith, Brian D., Vasudevan, Anju, ElKhal, Abdallah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205890/
https://www.ncbi.nlm.nih.gov/pubmed/25290058
http://dx.doi.org/10.1038/ncomms6101

Ejemplares similares

Ejemplares similares