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Diabetic kidney disease; review of the current knowledge

Diabetes is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in most parts of the world. 20 to 30% of diabetic patient have diabetic nephropathy in type 1 and type 2. Hyperglycemia is the key of nephropathy creation. Hyperglycemia also by production of toxic m...

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Detalles Bibliográficos
Autores principales: Shahbazian, Heshmatollah, Rezaii, Isa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nickan Research Institute 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206005/
https://www.ncbi.nlm.nih.gov/pubmed/25340133
http://dx.doi.org/10.12861/jrip.2013.24
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author Shahbazian, Heshmatollah
Rezaii, Isa
author_facet Shahbazian, Heshmatollah
Rezaii, Isa
author_sort Shahbazian, Heshmatollah
collection PubMed
description Diabetes is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in most parts of the world. 20 to 30% of diabetic patient have diabetic nephropathy in type 1 and type 2. Hyperglycemia is the key of nephropathy creation. Hyperglycemia also by production of toxic materials, advanced glycosylated end product (AGE), increased activity of aldose reductase has some role. Some metabolites of arachidonic acid, hemodynamic derangements and genetic factors have also some role. Although diabetic nephropathy is most common cause of nephropathy in these patients, but diabetic patients are also prone to other urinary tract and renal parenchymal disease and should not be confused with renal failure due to diabetic nephropathy. The principle of treatment of diabetic nephropathy is based on tight control of hyperglycemia, tight control of blood pressure and glomerular pressure, control of dyslipidemia, restriction of protein intake and smoking withdrawal.
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spelling pubmed-42060052014-10-22 Diabetic kidney disease; review of the current knowledge Shahbazian, Heshmatollah Rezaii, Isa J Renal Inj Prev Review Diabetes is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in most parts of the world. 20 to 30% of diabetic patient have diabetic nephropathy in type 1 and type 2. Hyperglycemia is the key of nephropathy creation. Hyperglycemia also by production of toxic materials, advanced glycosylated end product (AGE), increased activity of aldose reductase has some role. Some metabolites of arachidonic acid, hemodynamic derangements and genetic factors have also some role. Although diabetic nephropathy is most common cause of nephropathy in these patients, but diabetic patients are also prone to other urinary tract and renal parenchymal disease and should not be confused with renal failure due to diabetic nephropathy. The principle of treatment of diabetic nephropathy is based on tight control of hyperglycemia, tight control of blood pressure and glomerular pressure, control of dyslipidemia, restriction of protein intake and smoking withdrawal. Nickan Research Institute 2013-06-01 /pmc/articles/PMC4206005/ /pubmed/25340133 http://dx.doi.org/10.12861/jrip.2013.24 Text en Copyright © 2013 The Author(s); Published by Nickan Research Institute http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Shahbazian, Heshmatollah
Rezaii, Isa
Diabetic kidney disease; review of the current knowledge
title Diabetic kidney disease; review of the current knowledge
title_full Diabetic kidney disease; review of the current knowledge
title_fullStr Diabetic kidney disease; review of the current knowledge
title_full_unstemmed Diabetic kidney disease; review of the current knowledge
title_short Diabetic kidney disease; review of the current knowledge
title_sort diabetic kidney disease; review of the current knowledge
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206005/
https://www.ncbi.nlm.nih.gov/pubmed/25340133
http://dx.doi.org/10.12861/jrip.2013.24
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