IgM nephropathy: timely response to a call for action

Immunoglobulin M (IgM) is the largest antibody molecule and is deposited in the glomeruli in a wide variety of both primary and secondary glomerulopathies. The data on its pathogenic role are conflicting till date. A recent study provides evidence for the involvement of natural antibody IgM in fixin...

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Detalles Bibliográficos
Autores principales: Mubarak, Muhammed, Nasri, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nickan Research Institute 2013
Materias:
News and Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206037/
https://www.ncbi.nlm.nih.gov/pubmed/25340155
http://dx.doi.org/10.12861/jrip.2014.03
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author Mubarak, Muhammed
Nasri, Hamid
author_facet Mubarak, Muhammed
Nasri, Hamid
author_sort Mubarak, Muhammed
collection PubMed
description Immunoglobulin M (IgM) is the largest antibody molecule and is deposited in the glomeruli in a wide variety of both primary and secondary glomerulopathies. The data on its pathogenic role are conflicting till date. A recent study provides evidence for the involvement of natural antibody IgM in fixing and activating complement and causing glomerular injury, proteinuria, and glomerulosclerosis in an animal model. This finding is important in understanding the pathogenesis of the related disorder of IgM nephropathy.
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spelling pubmed-42060372014-10-22 IgM nephropathy: timely response to a call for action Mubarak, Muhammed Nasri, Hamid J Renal Inj Prev News and Views Immunoglobulin M (IgM) is the largest antibody molecule and is deposited in the glomeruli in a wide variety of both primary and secondary glomerulopathies. The data on its pathogenic role are conflicting till date. A recent study provides evidence for the involvement of natural antibody IgM in fixing and activating complement and causing glomerular injury, proteinuria, and glomerulosclerosis in an animal model. This finding is important in understanding the pathogenesis of the related disorder of IgM nephropathy. Nickan Research Institute 2013-11-02 /pmc/articles/PMC4206037/ /pubmed/25340155 http://dx.doi.org/10.12861/jrip.2014.03 Text en Copyright © 2014 The Author(s); Published by Nickan Research Institute http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle News and Views
Mubarak, Muhammed
Nasri, Hamid
IgM nephropathy: timely response to a call for action
title IgM nephropathy: timely response to a call for action
title_full IgM nephropathy: timely response to a call for action
title_fullStr IgM nephropathy: timely response to a call for action
title_full_unstemmed IgM nephropathy: timely response to a call for action
title_short IgM nephropathy: timely response to a call for action
title_sort igm nephropathy: timely response to a call for action
topic News and Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206037/
https://www.ncbi.nlm.nih.gov/pubmed/25340155
http://dx.doi.org/10.12861/jrip.2014.03
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