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Is Prophylactic Irradiation to Para-aortic Lymph Nodes in Locally Advanced Cervical Cancer Necessary?

PURPOSE: This study evaluated the efficacy of extended field irradiation (EFI) in patients with locally advanced cervical cancer without para-aortic nodal involvement. MATERIALS AND METHODS: A total of 203 patients with locally advanced cervical cancer (International Federation of Gynecology and Obs...

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Autores principales: Park, Seung Gyu, Kim, Jin Hee, Oh, Young Kee, Byun, Sang Jun, Kim, Mi Young, Kwon, Sang Hoon, Kim, Ok Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206071/
https://www.ncbi.nlm.nih.gov/pubmed/25043821
http://dx.doi.org/10.4143/crt.2013.084
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author Park, Seung Gyu
Kim, Jin Hee
Oh, Young Kee
Byun, Sang Jun
Kim, Mi Young
Kwon, Sang Hoon
Kim, Ok Bae
author_facet Park, Seung Gyu
Kim, Jin Hee
Oh, Young Kee
Byun, Sang Jun
Kim, Mi Young
Kwon, Sang Hoon
Kim, Ok Bae
author_sort Park, Seung Gyu
collection PubMed
description PURPOSE: This study evaluated the efficacy of extended field irradiation (EFI) in patients with locally advanced cervical cancer without para-aortic nodal involvement. MATERIALS AND METHODS: A total of 203 patients with locally advanced cervical cancer (International Federation of Gynecology and Obstetrics [FIGO] stage, IB2-IIIB) treated with radiotherapy at Keimyung University Dongsan Medical Center from 1996 to 2010 were retrospectively analyzed. The median patient age was 59 years (range, 29 to 83 years). None of the patients had para-aortic node metastases. Of the 203 patients, 88 underwent EFI and 115 underwent irradiation of the pelvis only. Concurrent chemoradiotherapy (CCRT) was administered to 133 patients. EFI field was used for treatment of 26 patients who received radiotherapy alone and 62 who received CCRT. RESULTS: The median follow-up period was 60 months. The 2- and 5-year overall survival (OS) rates were 87.8% and 73.5%, respectively, and the 2- and 5-year disease-free survival rates were 81.7% and 75.0%, respectively, however, no survival differences were observed between the two treatment field groups. EFI tended to increase OS in the radiotherapy alone group, but not in the CCRT group. CONCLUSION: These findings suggest that EFI does not have a significant effect in patients with locally advanced cervical cancer, especially in patients receiving CCRT. Conduct of additional studies will be required in order to confirm these findings.
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spelling pubmed-42060712014-10-24 Is Prophylactic Irradiation to Para-aortic Lymph Nodes in Locally Advanced Cervical Cancer Necessary? Park, Seung Gyu Kim, Jin Hee Oh, Young Kee Byun, Sang Jun Kim, Mi Young Kwon, Sang Hoon Kim, Ok Bae Cancer Res Treat Original Article PURPOSE: This study evaluated the efficacy of extended field irradiation (EFI) in patients with locally advanced cervical cancer without para-aortic nodal involvement. MATERIALS AND METHODS: A total of 203 patients with locally advanced cervical cancer (International Federation of Gynecology and Obstetrics [FIGO] stage, IB2-IIIB) treated with radiotherapy at Keimyung University Dongsan Medical Center from 1996 to 2010 were retrospectively analyzed. The median patient age was 59 years (range, 29 to 83 years). None of the patients had para-aortic node metastases. Of the 203 patients, 88 underwent EFI and 115 underwent irradiation of the pelvis only. Concurrent chemoradiotherapy (CCRT) was administered to 133 patients. EFI field was used for treatment of 26 patients who received radiotherapy alone and 62 who received CCRT. RESULTS: The median follow-up period was 60 months. The 2- and 5-year overall survival (OS) rates were 87.8% and 73.5%, respectively, and the 2- and 5-year disease-free survival rates were 81.7% and 75.0%, respectively, however, no survival differences were observed between the two treatment field groups. EFI tended to increase OS in the radiotherapy alone group, but not in the CCRT group. CONCLUSION: These findings suggest that EFI does not have a significant effect in patients with locally advanced cervical cancer, especially in patients receiving CCRT. Conduct of additional studies will be required in order to confirm these findings. Korean Cancer Association 2014-10 2014-07-21 /pmc/articles/PMC4206071/ /pubmed/25043821 http://dx.doi.org/10.4143/crt.2013.084 Text en Copyright © 2014 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Seung Gyu
Kim, Jin Hee
Oh, Young Kee
Byun, Sang Jun
Kim, Mi Young
Kwon, Sang Hoon
Kim, Ok Bae
Is Prophylactic Irradiation to Para-aortic Lymph Nodes in Locally Advanced Cervical Cancer Necessary?
title Is Prophylactic Irradiation to Para-aortic Lymph Nodes in Locally Advanced Cervical Cancer Necessary?
title_full Is Prophylactic Irradiation to Para-aortic Lymph Nodes in Locally Advanced Cervical Cancer Necessary?
title_fullStr Is Prophylactic Irradiation to Para-aortic Lymph Nodes in Locally Advanced Cervical Cancer Necessary?
title_full_unstemmed Is Prophylactic Irradiation to Para-aortic Lymph Nodes in Locally Advanced Cervical Cancer Necessary?
title_short Is Prophylactic Irradiation to Para-aortic Lymph Nodes in Locally Advanced Cervical Cancer Necessary?
title_sort is prophylactic irradiation to para-aortic lymph nodes in locally advanced cervical cancer necessary?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206071/
https://www.ncbi.nlm.nih.gov/pubmed/25043821
http://dx.doi.org/10.4143/crt.2013.084
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