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The contribution of hypothalamic macroglia to the regulation of energy homeostasis
The hypothalamus is critical for the regulation of energy homeostasis. Genetic and pharmacologic studies have identified a number of key hypothalamic neuronal circuits that integrate signals controlling food intake and energy expenditure. Recently, studies have begun to emerge demonstrating a role f...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206078/ https://www.ncbi.nlm.nih.gov/pubmed/25374514 http://dx.doi.org/10.3389/fnsys.2014.00212 |
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author | Buckman, Laura B. Ellacott, Kate L. J. |
author_facet | Buckman, Laura B. Ellacott, Kate L. J. |
author_sort | Buckman, Laura B. |
collection | PubMed |
description | The hypothalamus is critical for the regulation of energy homeostasis. Genetic and pharmacologic studies have identified a number of key hypothalamic neuronal circuits that integrate signals controlling food intake and energy expenditure. Recently, studies have begun to emerge demonstrating a role for non-neuronal cell types in the regulation of energy homeostasis. In particular the potential importance of different glial cell types is increasingly being recognized. A number of studies have described changes in the activity of hypothalamic macroglia (principally astrocytes and tanycytes) in response to states of positive and negative energy balance, such as obesity and fasting. This article will review these studies and discuss how these findings are changing our understanding of the cellular mechanisms by which energy homeostasis is regulated. |
format | Online Article Text |
id | pubmed-4206078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42060782014-11-05 The contribution of hypothalamic macroglia to the regulation of energy homeostasis Buckman, Laura B. Ellacott, Kate L. J. Front Syst Neurosci Neuroscience The hypothalamus is critical for the regulation of energy homeostasis. Genetic and pharmacologic studies have identified a number of key hypothalamic neuronal circuits that integrate signals controlling food intake and energy expenditure. Recently, studies have begun to emerge demonstrating a role for non-neuronal cell types in the regulation of energy homeostasis. In particular the potential importance of different glial cell types is increasingly being recognized. A number of studies have described changes in the activity of hypothalamic macroglia (principally astrocytes and tanycytes) in response to states of positive and negative energy balance, such as obesity and fasting. This article will review these studies and discuss how these findings are changing our understanding of the cellular mechanisms by which energy homeostasis is regulated. Frontiers Media S.A. 2014-10-22 /pmc/articles/PMC4206078/ /pubmed/25374514 http://dx.doi.org/10.3389/fnsys.2014.00212 Text en Copyright © 2014 Buckman and Ellacott. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Buckman, Laura B. Ellacott, Kate L. J. The contribution of hypothalamic macroglia to the regulation of energy homeostasis |
title | The contribution of hypothalamic macroglia to the regulation of energy homeostasis |
title_full | The contribution of hypothalamic macroglia to the regulation of energy homeostasis |
title_fullStr | The contribution of hypothalamic macroglia to the regulation of energy homeostasis |
title_full_unstemmed | The contribution of hypothalamic macroglia to the regulation of energy homeostasis |
title_short | The contribution of hypothalamic macroglia to the regulation of energy homeostasis |
title_sort | contribution of hypothalamic macroglia to the regulation of energy homeostasis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206078/ https://www.ncbi.nlm.nih.gov/pubmed/25374514 http://dx.doi.org/10.3389/fnsys.2014.00212 |
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