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Regulation of 53BP1 Protein Stability by RNF8 and RNF168 Is Important for Efficient DNA Double-Strand Break Repair

53BP1 regulates DNA double-strand break (DSB) repair. In functional assays for specific DSB repair pathways, we found that 53BP1 was important in the conservative non-homologous end-joining (C-NHEJ) pathway, and this activity was dependent upon RNF8 and RNF168. We observed that 53BP1 protein was dif...

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Detalles Bibliográficos
Autores principales:	Hu, Yiheng, Wang, Chao, Huang, Kun, Xia, Fen, Parvin, Jeffrey D., Mondal, Neelima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206297/ https://www.ncbi.nlm.nih.gov/pubmed/25337968 http://dx.doi.org/10.1371/journal.pone.0110522

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