Cargando…

A Novel Aminothiazole KY-05009 with Potential to Inhibit Traf2- and Nck-Interacting Kinase (TNIK) Attenuates TGF-β1-Mediated Epithelial-to-Mesenchymal Transition in Human Lung Adenocarcinoma A549 Cells

Transforming growth factor (TGF)-β triggers the epithelial-to-mesenchymal transition (EMT) of cancer cells via well-orchestrated crosstalk between Smad and non-Smad signaling pathways, including Wnt/β-catenin. Since EMT-induced motility and invasion play a critical role in cancer metastasis, EMT-rel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Jiyeon, Moon, Seong-Hee, Kim, Bum Tae, Chae, Chong Hak, Lee, Joo Yun, Kim, Seong Hwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206343/ https://www.ncbi.nlm.nih.gov/pubmed/25337707 http://dx.doi.org/10.1371/journal.pone.0110180

Ejemplares similares

Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells
por: Lee, Yura, et al.
Publicado: (2017)

Expression analysis of TRAF2‑ and NCK‑interacting protein kinase (TNIK) and phosphorylated TNIK in papillary thyroid carcinoma
por: Li, Jiali, et al.
Publicado: (2023)

Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer
por: Takahashi, Hidenori, et al.
Publicado: (2015)

Computational study on new natural compound inhibitors of Traf2 and Nck-interacting kinase (TNIK)
por: Ma, Lushun, et al.
Publicado: (2022)

Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis
por: van Os, Bram W., et al.
Publicado: (2023)

CK2 Inhibitor CX-4945 Blocks TGF-β1-Induced Epithelial-to-Mesenchymal Transition in A549 Human Lung Adenocarcinoma Cells
por: Kim, Jiyeon, et al.
Publicado: (2013)

Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma
por: Sekita, Tetsuya, et al.
Publicado: (2020)

Structural Insight into TNIK Inhibition
por: Kukimoto-Niino, Mutsuko, et al.
Publicado: (2022)

Comprehensive Modeling and Discovery of Mebendazole as a Novel TRAF2- and NCK-interacting Kinase Inhibitor
por: Tan, Zhi, et al.
Publicado: (2016)

Emergence of TNIK inhibitors in cancer therapeutics
por: Yamada, Tesshi, et al.
Publicado: (2017)

Tetrakis(2-aminothiazole-κN (3))dichloridocadmium(II)
por: Kim, Chong-Hyeak, et al.
Publicado: (2009)

Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice
por: Buchl, Samuel C., et al.
Publicado: (2021)

Nck by the numbers
por: Leslie, Mitch
Publicado: (2012)

TNIK inhibition abrogates colorectal cancer stemness
por: Masuda, Mari, et al.
Publicado: (2016)

Direct conversion of osteosarcoma to adipocytes by targeting TNIK
por: Hirozane, Toru, et al.
Publicado: (2021)

Comparative Genomic Sequencing and Pathogenic Properties of Equine Herpesvirus 1 KyA and RacL11
por: Shakya, Akhalesh K., et al.
Publicado: (2017)

TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells
por: Kim, Jaehee, et al.
Publicado: (2022)

Pharmacological blockage of transforming growth factor-β signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-0846
por: Sugano, Teppei, et al.
Publicado: (2020)

The Physicians of Oldham County, Ky.
Publicado: (1875)

Letter from Louisville, Ky.
por: Cheatham, W.
Publicado: (1882)

Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation
por: Ngoenkam, Jatuporn, et al.
Publicado: (2014)

Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development
por: Golding, Adam P., et al.
Publicado: (2023)

The essential role of TNIK gene amplification in gastric cancer growth
por: Yu, D-H, et al.
Publicado: (2014)

The essential role of TNIK gene amplification in gastric cancer growth
por: Yu, D-H, et al.
Publicado: (2014)

TNIK is a conserved regulator of glucose and lipid metabolism in obesity
por: Pham, T. C. Phung, et al.
Publicado: (2023)

TRAF6 Mediates IL-1β/LPS-Induced Suppression of TGF-β Signaling through Its Interaction with the Type III TGF-β Receptor
por: Lim, Seunghwan, et al.
Publicado: (2012)

Letter from New Castle, Ky.
por: Culver, C. P.
Publicado: (1853)

Medico-Chirurgical Society of Louisville, Ky.
Publicado: (1881)

The Streptococcus Epidemic at Camp Taylor, Ky.
Publicado: (1918)

KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis
por: Ryu, Yeong Chan, et al.
Publicado: (2021)

Synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives
por: Khabnadideh, S., et al.
Publicado: (2012)

Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents
por: Kesicki, Edward A., et al.
Publicado: (2016)

Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis
por: Wescott, Heather H., et al.
Publicado: (2018)

QSAR study of anti-prion activity of 2-aminothiazoles
por: Mandi, Prasit, et al.
Publicado: (2012)

Endothelial NCK2 promotes atherosclerosis progression in male but not female Nck1-null atheroprone mice
por: Bywaters, Briana C., et al.
Publicado: (2022)

Lack of Nck1 protein and Nck-CD3 interaction caused the increment of lipid content in Jurkat T cells
por: Nuiyen, Aussanee, et al.
Publicado: (2022)

Pneumonia and Empyema at Camp Zachary Taylor, Ky.
Publicado: (1918)

Agonistic and Antagonistic Roles for TNIK and MINK in Non-Canonical and Canonical Wnt Signalling
por: Mikryukov, Alexander, et al.
Publicado: (2012)

Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds
por: Papadopoulou, Maria V., et al.
Publicado: (2016)

Synthesis and Evaluation of Aminothiazole-Paeonol Derivatives as Potential Anticancer Agents
por: Tsai, Chia-Ying, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_26ftse7o0u9p7dtfla9q8ktt7a