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Obesity Preserves Myocardial Function During Blockade of the Glycolytic Pathway

BACKGROUND: Obesity is defined by excessive accumulation of body fat relative to lean tissue. Studies during the last few years indicate that cardiac function in obese animals may be preserved, increased or diminished. OBJECTIVE: Study the energy balance of the myocardium with the hypothesis that th...

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Autores principales: de Campos, Dijon Henrique Salomé, Leopoldo, André Soares, Lima-Leopoldo, Ana Paula, do Nascimento, André Ferreira, de Oliveira-Junior, Silvio Assis, da Silva, Danielle Cristina Tomaz, Sugizaki, Mario Mateus, Padovani, Carlos Roberto, Cicogna, Antonio Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206364/
https://www.ncbi.nlm.nih.gov/pubmed/25352507
http://dx.doi.org/10.5935/abc.20140135
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author de Campos, Dijon Henrique Salomé
Leopoldo, André Soares
Lima-Leopoldo, Ana Paula
do Nascimento, André Ferreira
de Oliveira-Junior, Silvio Assis
da Silva, Danielle Cristina Tomaz
Sugizaki, Mario Mateus
Padovani, Carlos Roberto
Cicogna, Antonio Carlos
author_facet de Campos, Dijon Henrique Salomé
Leopoldo, André Soares
Lima-Leopoldo, Ana Paula
do Nascimento, André Ferreira
de Oliveira-Junior, Silvio Assis
da Silva, Danielle Cristina Tomaz
Sugizaki, Mario Mateus
Padovani, Carlos Roberto
Cicogna, Antonio Carlos
author_sort de Campos, Dijon Henrique Salomé
collection PubMed
description BACKGROUND: Obesity is defined by excessive accumulation of body fat relative to lean tissue. Studies during the last few years indicate that cardiac function in obese animals may be preserved, increased or diminished. OBJECTIVE: Study the energy balance of the myocardium with the hypothesis that the increase in fatty acid oxidation and reduced glucose leads to cardiac dysfunction in obesity. METHODS: 30-day-old male Wistar rats were fed standard and hypercaloric diet for 30 weeks. Cardiac function and morphology were assessed. In this paper was viewed the general characteristics and comorbities associated to obesity. The structure cardiac was determined by weights of the heart and left ventricle (LV). Myocardial function was evaluated by studying isolated papillary muscles from the LV, under the baseline condition and after inotropic and lusitropic maneuvers: myocardial stiffness; postrest contraction; increase in extracellular Ca2+ concentration; change in heart rate and inhibitor of glycolytic pathway. RESULTS: Compared with control group, the obese rats had increased body fat and co-morbities associated with obesity. Functional assessment after blocking iodoacetate shows no difference in the linear regression of DT, however, the RT showed a statistically significant difference in behavior between the control and the obese group, most notable being the slope in group C. CONCLUSION: The energy imbalance on obesity did not cause cardiac dysfunction. On the contrary, the prioritization of fatty acids utilization provides protection to cardiac muscle during the inhibition of glycolysis, suggesting that this pathway is fewer used by obese cardiac muscle.
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spelling pubmed-42063642014-10-23 Obesity Preserves Myocardial Function During Blockade of the Glycolytic Pathway de Campos, Dijon Henrique Salomé Leopoldo, André Soares Lima-Leopoldo, Ana Paula do Nascimento, André Ferreira de Oliveira-Junior, Silvio Assis da Silva, Danielle Cristina Tomaz Sugizaki, Mario Mateus Padovani, Carlos Roberto Cicogna, Antonio Carlos Arq Bras Cardiol Original Articles BACKGROUND: Obesity is defined by excessive accumulation of body fat relative to lean tissue. Studies during the last few years indicate that cardiac function in obese animals may be preserved, increased or diminished. OBJECTIVE: Study the energy balance of the myocardium with the hypothesis that the increase in fatty acid oxidation and reduced glucose leads to cardiac dysfunction in obesity. METHODS: 30-day-old male Wistar rats were fed standard and hypercaloric diet for 30 weeks. Cardiac function and morphology were assessed. In this paper was viewed the general characteristics and comorbities associated to obesity. The structure cardiac was determined by weights of the heart and left ventricle (LV). Myocardial function was evaluated by studying isolated papillary muscles from the LV, under the baseline condition and after inotropic and lusitropic maneuvers: myocardial stiffness; postrest contraction; increase in extracellular Ca2+ concentration; change in heart rate and inhibitor of glycolytic pathway. RESULTS: Compared with control group, the obese rats had increased body fat and co-morbities associated with obesity. Functional assessment after blocking iodoacetate shows no difference in the linear regression of DT, however, the RT showed a statistically significant difference in behavior between the control and the obese group, most notable being the slope in group C. CONCLUSION: The energy imbalance on obesity did not cause cardiac dysfunction. On the contrary, the prioritization of fatty acids utilization provides protection to cardiac muscle during the inhibition of glycolysis, suggesting that this pathway is fewer used by obese cardiac muscle. Sociedade Brasileira de Cardiologia 2014-10 /pmc/articles/PMC4206364/ /pubmed/25352507 http://dx.doi.org/10.5935/abc.20140135 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
de Campos, Dijon Henrique Salomé
Leopoldo, André Soares
Lima-Leopoldo, Ana Paula
do Nascimento, André Ferreira
de Oliveira-Junior, Silvio Assis
da Silva, Danielle Cristina Tomaz
Sugizaki, Mario Mateus
Padovani, Carlos Roberto
Cicogna, Antonio Carlos
Obesity Preserves Myocardial Function During Blockade of the Glycolytic Pathway
title Obesity Preserves Myocardial Function During Blockade of the Glycolytic Pathway
title_full Obesity Preserves Myocardial Function During Blockade of the Glycolytic Pathway
title_fullStr Obesity Preserves Myocardial Function During Blockade of the Glycolytic Pathway
title_full_unstemmed Obesity Preserves Myocardial Function During Blockade of the Glycolytic Pathway
title_short Obesity Preserves Myocardial Function During Blockade of the Glycolytic Pathway
title_sort obesity preserves myocardial function during blockade of the glycolytic pathway
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206364/
https://www.ncbi.nlm.nih.gov/pubmed/25352507
http://dx.doi.org/10.5935/abc.20140135
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