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Tardive dyskinesia in a South Asian population with first episode psychosis treated with antipsychotics

BACKGROUND: Tardive dyskinesia (TD) is a side effect of antipsychotic treatment that often only appears after months or years of treatment. A systematic review of randomized controlled trials lasting more than 1 year showed that second-generation antipsychotics (SGAs) were associated with an approxi...

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Autores principales: Adam, Usman U, Husain, Nusrat, Haddad, Peter M, Munshi, Tariq, Tariq, Fauzia, Naeem, Farooq, Chaudhry, Imran B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206401/
https://www.ncbi.nlm.nih.gov/pubmed/25342903
http://dx.doi.org/10.2147/NDT.S68297
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author Adam, Usman U
Husain, Nusrat
Haddad, Peter M
Munshi, Tariq
Tariq, Fauzia
Naeem, Farooq
Chaudhry, Imran B
author_facet Adam, Usman U
Husain, Nusrat
Haddad, Peter M
Munshi, Tariq
Tariq, Fauzia
Naeem, Farooq
Chaudhry, Imran B
author_sort Adam, Usman U
collection PubMed
description BACKGROUND: Tardive dyskinesia (TD) is a side effect of antipsychotic treatment that often only appears after months or years of treatment. A systematic review of randomized controlled trials lasting more than 1 year showed that second-generation antipsychotics (SGAs) were associated with an approximately fivefold lower risk of TD compared to haloperidol in patients with chronic schizophrenia. In contrast, there is little research on the risk of TD with other first-generation antipsychotics (FGAs), and this applies especially to their use in the treatment of patients with first episode psychosis (FEP). OBJECTIVES: To determine the severity and point prevalence of TD in a naturalistic sample of patients with FEP in Pakistan treated with FGAs or SGAs. METHODS: This was an observational study. TD was assessed by trained clinicians using the Abnormal Involuntary Movement Scale. RESULTS: In the total sample (number =86) the mean age of patients was 26 years and the prevalence of TD (Schooler Kane criteria) was 29% with no significant difference between those treated with FGAs and SGAs (31% FGAs versus 26% SGAs; P=0.805). The Abnormal Involuntary Movement Scale total score (items 1–7), a measure of the severity of TD, was significantly higher for patients treated with FGAs versus those treated with SGAs (P=0.033). Scores on specific items showed that this reflected higher scores for dyskinesia affecting the muscles of facial expression, as well as of the upper and lower limb, whereas scores did not differ significantly in other body areas. CONCLUSION: FGAs were associated with greater severity, though not prevalence, of TD than SGAs. The study highlights the relatively high rate of TD in Asian FEP patients and the need for clinicians to monitor for this and other potential antipsychotic side effects during treatment.
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spelling pubmed-42064012014-10-23 Tardive dyskinesia in a South Asian population with first episode psychosis treated with antipsychotics Adam, Usman U Husain, Nusrat Haddad, Peter M Munshi, Tariq Tariq, Fauzia Naeem, Farooq Chaudhry, Imran B Neuropsychiatr Dis Treat Original Research BACKGROUND: Tardive dyskinesia (TD) is a side effect of antipsychotic treatment that often only appears after months or years of treatment. A systematic review of randomized controlled trials lasting more than 1 year showed that second-generation antipsychotics (SGAs) were associated with an approximately fivefold lower risk of TD compared to haloperidol in patients with chronic schizophrenia. In contrast, there is little research on the risk of TD with other first-generation antipsychotics (FGAs), and this applies especially to their use in the treatment of patients with first episode psychosis (FEP). OBJECTIVES: To determine the severity and point prevalence of TD in a naturalistic sample of patients with FEP in Pakistan treated with FGAs or SGAs. METHODS: This was an observational study. TD was assessed by trained clinicians using the Abnormal Involuntary Movement Scale. RESULTS: In the total sample (number =86) the mean age of patients was 26 years and the prevalence of TD (Schooler Kane criteria) was 29% with no significant difference between those treated with FGAs and SGAs (31% FGAs versus 26% SGAs; P=0.805). The Abnormal Involuntary Movement Scale total score (items 1–7), a measure of the severity of TD, was significantly higher for patients treated with FGAs versus those treated with SGAs (P=0.033). Scores on specific items showed that this reflected higher scores for dyskinesia affecting the muscles of facial expression, as well as of the upper and lower limb, whereas scores did not differ significantly in other body areas. CONCLUSION: FGAs were associated with greater severity, though not prevalence, of TD than SGAs. The study highlights the relatively high rate of TD in Asian FEP patients and the need for clinicians to monitor for this and other potential antipsychotic side effects during treatment. Dove Medical Press 2014-10-14 /pmc/articles/PMC4206401/ /pubmed/25342903 http://dx.doi.org/10.2147/NDT.S68297 Text en © 2014 Adam et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Adam, Usman U
Husain, Nusrat
Haddad, Peter M
Munshi, Tariq
Tariq, Fauzia
Naeem, Farooq
Chaudhry, Imran B
Tardive dyskinesia in a South Asian population with first episode psychosis treated with antipsychotics
title Tardive dyskinesia in a South Asian population with first episode psychosis treated with antipsychotics
title_full Tardive dyskinesia in a South Asian population with first episode psychosis treated with antipsychotics
title_fullStr Tardive dyskinesia in a South Asian population with first episode psychosis treated with antipsychotics
title_full_unstemmed Tardive dyskinesia in a South Asian population with first episode psychosis treated with antipsychotics
title_short Tardive dyskinesia in a South Asian population with first episode psychosis treated with antipsychotics
title_sort tardive dyskinesia in a south asian population with first episode psychosis treated with antipsychotics
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206401/
https://www.ncbi.nlm.nih.gov/pubmed/25342903
http://dx.doi.org/10.2147/NDT.S68297
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