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Contributions of the social environment to first-onset and recurrent mania
In treated cohorts, individuals with bipolar disorder are more likely to report childhood adversities and recent stressors than individuals without bipolar disorder; similarly, in registry-based studies, childhood adversities are more common among individuals who later become hospitalized for bipola...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206672/ https://www.ncbi.nlm.nih.gov/pubmed/24751965 http://dx.doi.org/10.1038/mp.2014.36 |
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author | Gilman, Stephen E. Ni, Michael Y. Dunn, Erin C. Breslau, Joshua McLaughlin, Katie A. Smoller, Jordan W. Perlis, Roy H. |
author_facet | Gilman, Stephen E. Ni, Michael Y. Dunn, Erin C. Breslau, Joshua McLaughlin, Katie A. Smoller, Jordan W. Perlis, Roy H. |
author_sort | Gilman, Stephen E. |
collection | PubMed |
description | In treated cohorts, individuals with bipolar disorder are more likely to report childhood adversities and recent stressors than individuals without bipolar disorder; similarly, in registry-based studies, childhood adversities are more common among individuals who later become hospitalized for bipolar disorder. Because these types of studies rely on treatment-seeking samples or hospital diagnoses, they leave unresolved the question of whether or not social experiences are involved in the etiology of bipolar disorder. We investigated the role of childhood adversities and adulthood stressors in liability for bipolar disorder using data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, n=33,375). We analyzed risk for initial-onset and recurrent DSM-IV manic episodes during the study’s 3-year follow-up period. Childhood physical abuse and sexual maltreatment were associated with significantly higher risks of both first onset mania (odds ratio (OR) for abuse: 2.23; 95% confidence interval (CI): 1.71–2.91; OR for maltreatment: 2.10; CI: 1.55–2.83) and recurrent mania (OR for abuse: 1.55; CI: 1.00–2.40; OR for maltreatment: 1.60; CI=1.00–2.55). In addition, past-year stressors in the domains of interpersonal instability and financial hardship were associated with a significantly higher risk of incident and recurrent mania. Exposure to childhood adversity potentiated the effects of recent stressors on adult mania. Our findings demonstrate a role of social experiences in the initial onset of bipolar disorder, as well as in its prospective course, and are consistent with etiologic models of bipolar disorder that implicate deficits in developmentally established stress-response pathways. |
format | Online Article Text |
id | pubmed-4206672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-42066722015-09-01 Contributions of the social environment to first-onset and recurrent mania Gilman, Stephen E. Ni, Michael Y. Dunn, Erin C. Breslau, Joshua McLaughlin, Katie A. Smoller, Jordan W. Perlis, Roy H. Mol Psychiatry Article In treated cohorts, individuals with bipolar disorder are more likely to report childhood adversities and recent stressors than individuals without bipolar disorder; similarly, in registry-based studies, childhood adversities are more common among individuals who later become hospitalized for bipolar disorder. Because these types of studies rely on treatment-seeking samples or hospital diagnoses, they leave unresolved the question of whether or not social experiences are involved in the etiology of bipolar disorder. We investigated the role of childhood adversities and adulthood stressors in liability for bipolar disorder using data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, n=33,375). We analyzed risk for initial-onset and recurrent DSM-IV manic episodes during the study’s 3-year follow-up period. Childhood physical abuse and sexual maltreatment were associated with significantly higher risks of both first onset mania (odds ratio (OR) for abuse: 2.23; 95% confidence interval (CI): 1.71–2.91; OR for maltreatment: 2.10; CI: 1.55–2.83) and recurrent mania (OR for abuse: 1.55; CI: 1.00–2.40; OR for maltreatment: 1.60; CI=1.00–2.55). In addition, past-year stressors in the domains of interpersonal instability and financial hardship were associated with a significantly higher risk of incident and recurrent mania. Exposure to childhood adversity potentiated the effects of recent stressors on adult mania. Our findings demonstrate a role of social experiences in the initial onset of bipolar disorder, as well as in its prospective course, and are consistent with etiologic models of bipolar disorder that implicate deficits in developmentally established stress-response pathways. 2014-04-22 2015-03 /pmc/articles/PMC4206672/ /pubmed/24751965 http://dx.doi.org/10.1038/mp.2014.36 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Gilman, Stephen E. Ni, Michael Y. Dunn, Erin C. Breslau, Joshua McLaughlin, Katie A. Smoller, Jordan W. Perlis, Roy H. Contributions of the social environment to first-onset and recurrent mania |
title | Contributions of the social environment to first-onset and recurrent mania |
title_full | Contributions of the social environment to first-onset and recurrent mania |
title_fullStr | Contributions of the social environment to first-onset and recurrent mania |
title_full_unstemmed | Contributions of the social environment to first-onset and recurrent mania |
title_short | Contributions of the social environment to first-onset and recurrent mania |
title_sort | contributions of the social environment to first-onset and recurrent mania |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206672/ https://www.ncbi.nlm.nih.gov/pubmed/24751965 http://dx.doi.org/10.1038/mp.2014.36 |
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