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Total Synthesis of (−)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy
[Image: see text] The first total synthesis of N-methylwelwitindolinone B isothiocyanate is reported. The route features several key steps, including a regio- and diastereoselective chlorinative oxabicycle ring-opening reaction to introduce the challenging alkyl chloride motif.
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206695/ https://www.ncbi.nlm.nih.gov/pubmed/25275668 http://dx.doi.org/10.1021/ja5087672 |
| _version_ | 1782340850879037440 |
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| author | Weires, Nicholas A. Styduhar, Evan D. Baker, Emma L. Garg, Neil K. |
| author_facet | Weires, Nicholas A. Styduhar, Evan D. Baker, Emma L. Garg, Neil K. |
| author_sort | Weires, Nicholas A. |
| collection | PubMed |
| description | [Image: see text] The first total synthesis of N-methylwelwitindolinone B isothiocyanate is reported. The route features several key steps, including a regio- and diastereoselective chlorinative oxabicycle ring-opening reaction to introduce the challenging alkyl chloride motif. |
| format | Online Article Text |
| id | pubmed-4206695 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | American Chemical
Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-42066952015-10-02 Total Synthesis of (−)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy Weires, Nicholas A. Styduhar, Evan D. Baker, Emma L. Garg, Neil K. J Am Chem Soc [Image: see text] The first total synthesis of N-methylwelwitindolinone B isothiocyanate is reported. The route features several key steps, including a regio- and diastereoselective chlorinative oxabicycle ring-opening reaction to introduce the challenging alkyl chloride motif. American Chemical Society 2014-10-02 2014-10-22 /pmc/articles/PMC4206695/ /pubmed/25275668 http://dx.doi.org/10.1021/ja5087672 Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) |
| spellingShingle | Weires, Nicholas A. Styduhar, Evan D. Baker, Emma L. Garg, Neil K. Total Synthesis of (−)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy |
| title | Total Synthesis
of (−)-N-Methylwelwitindolinone
B Isothiocyanate via a Chlorinative
Oxabicycle Ring-Opening Strategy |
| title_full | Total Synthesis
of (−)-N-Methylwelwitindolinone
B Isothiocyanate via a Chlorinative
Oxabicycle Ring-Opening Strategy |
| title_fullStr | Total Synthesis
of (−)-N-Methylwelwitindolinone
B Isothiocyanate via a Chlorinative
Oxabicycle Ring-Opening Strategy |
| title_full_unstemmed | Total Synthesis
of (−)-N-Methylwelwitindolinone
B Isothiocyanate via a Chlorinative
Oxabicycle Ring-Opening Strategy |
| title_short | Total Synthesis
of (−)-N-Methylwelwitindolinone
B Isothiocyanate via a Chlorinative
Oxabicycle Ring-Opening Strategy |
| title_sort | total synthesis
of (−)-n-methylwelwitindolinone
b isothiocyanate via a chlorinative
oxabicycle ring-opening strategy |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206695/ https://www.ncbi.nlm.nih.gov/pubmed/25275668 http://dx.doi.org/10.1021/ja5087672 |
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