Total Synthesis of (−)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy

[Image: see text] The first total synthesis of N-methylwelwitindolinone B isothiocyanate is reported. The route features several key steps, including a regio- and diastereoselective chlorinative oxabicycle ring-opening reaction to introduce the challenging alkyl chloride motif.

Detalles Bibliográficos
Autores principales: Weires, Nicholas A., Styduhar, Evan D., Baker, Emma L., Garg, Neil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206695/
https://www.ncbi.nlm.nih.gov/pubmed/25275668
http://dx.doi.org/10.1021/ja5087672

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