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Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells
Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression, respec...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206729/ https://www.ncbi.nlm.nih.gov/pubmed/25059280 http://dx.doi.org/10.5483/BMBRep.2014.47.9.149 |
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author | Hwang, Yu-Jin Song, Jaewhan Kim, Haeng-Ran Hwang, Kyung-A |
author_facet | Hwang, Yu-Jin Song, Jaewhan Kim, Haeng-Ran Hwang, Kyung-A |
author_sort | Hwang, Yu-Jin |
collection | PubMed |
description | Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression, respectively. Studies have shown that many natural dietary compounds regulate NF-κB and Nrf2, preventing inflammation and oxidative stress. Here, we report major compounds of Prunella vulgaris var. lilacina such as rosmarinic acid, oleanolic acid, ursolic acid and caffeic acid as a potential therapeutic for oxidative stress and inflammation. The major compounds exhibited high anti-inflammatory activity, inhibiting NO, PGE2 production, NF-κB expression and activating Nrf2 expression. In addition, we examined the effect of major compounds on MafK expression. Among the compounds, oleanolic acid significantly decreased MafK expression and MafK-mediated p65 acetylation. These findings suggest that oleanolic acid as NF-κB inhibitors can potentially be used in therapeutic applications for the treatment of oxidative stressnduced diseases. [BMB Reports 2014; 47(9): 524-529] |
format | Online Article Text |
id | pubmed-4206729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-42067292014-10-30 Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells Hwang, Yu-Jin Song, Jaewhan Kim, Haeng-Ran Hwang, Kyung-A BMB Rep Research Articles Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression, respectively. Studies have shown that many natural dietary compounds regulate NF-κB and Nrf2, preventing inflammation and oxidative stress. Here, we report major compounds of Prunella vulgaris var. lilacina such as rosmarinic acid, oleanolic acid, ursolic acid and caffeic acid as a potential therapeutic for oxidative stress and inflammation. The major compounds exhibited high anti-inflammatory activity, inhibiting NO, PGE2 production, NF-κB expression and activating Nrf2 expression. In addition, we examined the effect of major compounds on MafK expression. Among the compounds, oleanolic acid significantly decreased MafK expression and MafK-mediated p65 acetylation. These findings suggest that oleanolic acid as NF-κB inhibitors can potentially be used in therapeutic applications for the treatment of oxidative stressnduced diseases. [BMB Reports 2014; 47(9): 524-529] Korean Society for Biochemistry and Molecular Biology 2014-09 /pmc/articles/PMC4206729/ /pubmed/25059280 http://dx.doi.org/10.5483/BMBRep.2014.47.9.149 Text en Copyright © 2014, Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Hwang, Yu-Jin Song, Jaewhan Kim, Haeng-Ran Hwang, Kyung-A Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells |
title | Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells |
title_full | Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells |
title_fullStr | Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells |
title_full_unstemmed | Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells |
title_short | Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells |
title_sort | oleanolic acid regulates nf-κb signaling by suppressing mafk expression in raw 264.7 cells |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206729/ https://www.ncbi.nlm.nih.gov/pubmed/25059280 http://dx.doi.org/10.5483/BMBRep.2014.47.9.149 |
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