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Three-Dimensional Algebraic Models of the tRNA Code and 12 Graphs for Representing the Amino Acids

Three-dimensional algebraic models, also called Genetic Hotels, are developed to represent the Standard Genetic Code, the Standard tRNA Code (S-tRNA-C), and the Human tRNA code (H-tRNA-C). New algebraic concepts are introduced to be able to describe these models, to wit, the generalization of the 2(...

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Autores principales: José, Marco V., Morgado, Eberto R., Guimarães, Romeu Cardoso, Zamudio, Gabriel S., de Farías, Sávio Torres, Bobadilla, Juan R., Sosa, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206851/
https://www.ncbi.nlm.nih.gov/pubmed/25370377
http://dx.doi.org/10.3390/life4030341
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author José, Marco V.
Morgado, Eberto R.
Guimarães, Romeu Cardoso
Zamudio, Gabriel S.
de Farías, Sávio Torres
Bobadilla, Juan R.
Sosa, Daniela
author_facet José, Marco V.
Morgado, Eberto R.
Guimarães, Romeu Cardoso
Zamudio, Gabriel S.
de Farías, Sávio Torres
Bobadilla, Juan R.
Sosa, Daniela
author_sort José, Marco V.
collection PubMed
description Three-dimensional algebraic models, also called Genetic Hotels, are developed to represent the Standard Genetic Code, the Standard tRNA Code (S-tRNA-C), and the Human tRNA code (H-tRNA-C). New algebraic concepts are introduced to be able to describe these models, to wit, the generalization of the 2(n)-Klein Group and the concept of a subgroup coset with a tail. We found that the H-tRNA-C displayed broken symmetries in regard to the S-tRNA-C, which is highly symmetric. We also show that there are only 12 ways to represent each of the corresponding phenotypic graphs of amino acids. The averages of statistical centrality measures of the 12 graphs for each of the three codes are carried out and they are statistically compared. The phenotypic graphs of the S-tRNA-C display a common triangular prism of amino acids in 10 out of the 12 graphs, whilst the corresponding graphs for the H-tRNA-C display only two triangular prisms. The graphs exhibit disjoint clusters of amino acids when their polar requirement values are used. We contend that the S-tRNA-C is in a frozen-like state, whereas the H-tRNA-C may be in an evolving state.
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spelling pubmed-42068512014-10-27 Three-Dimensional Algebraic Models of the tRNA Code and 12 Graphs for Representing the Amino Acids José, Marco V. Morgado, Eberto R. Guimarães, Romeu Cardoso Zamudio, Gabriel S. de Farías, Sávio Torres Bobadilla, Juan R. Sosa, Daniela Life (Basel) Article Three-dimensional algebraic models, also called Genetic Hotels, are developed to represent the Standard Genetic Code, the Standard tRNA Code (S-tRNA-C), and the Human tRNA code (H-tRNA-C). New algebraic concepts are introduced to be able to describe these models, to wit, the generalization of the 2(n)-Klein Group and the concept of a subgroup coset with a tail. We found that the H-tRNA-C displayed broken symmetries in regard to the S-tRNA-C, which is highly symmetric. We also show that there are only 12 ways to represent each of the corresponding phenotypic graphs of amino acids. The averages of statistical centrality measures of the 12 graphs for each of the three codes are carried out and they are statistically compared. The phenotypic graphs of the S-tRNA-C display a common triangular prism of amino acids in 10 out of the 12 graphs, whilst the corresponding graphs for the H-tRNA-C display only two triangular prisms. The graphs exhibit disjoint clusters of amino acids when their polar requirement values are used. We contend that the S-tRNA-C is in a frozen-like state, whereas the H-tRNA-C may be in an evolving state. MDPI 2014-08-11 /pmc/articles/PMC4206851/ /pubmed/25370377 http://dx.doi.org/10.3390/life4030341 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
José, Marco V.
Morgado, Eberto R.
Guimarães, Romeu Cardoso
Zamudio, Gabriel S.
de Farías, Sávio Torres
Bobadilla, Juan R.
Sosa, Daniela
Three-Dimensional Algebraic Models of the tRNA Code and 12 Graphs for Representing the Amino Acids
title Three-Dimensional Algebraic Models of the tRNA Code and 12 Graphs for Representing the Amino Acids
title_full Three-Dimensional Algebraic Models of the tRNA Code and 12 Graphs for Representing the Amino Acids
title_fullStr Three-Dimensional Algebraic Models of the tRNA Code and 12 Graphs for Representing the Amino Acids
title_full_unstemmed Three-Dimensional Algebraic Models of the tRNA Code and 12 Graphs for Representing the Amino Acids
title_short Three-Dimensional Algebraic Models of the tRNA Code and 12 Graphs for Representing the Amino Acids
title_sort three-dimensional algebraic models of the trna code and 12 graphs for representing the amino acids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206851/
https://www.ncbi.nlm.nih.gov/pubmed/25370377
http://dx.doi.org/10.3390/life4030341
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