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New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3

aHUS (atypical haemolytic uraemic syndrome), AMD (age-related macular degeneration) and other diseases are associated with defective AP (alternative pathway) regulation. CFH (complement factor H), CFI (complement factor I), MCP (membrane cofactor protein) and C3 exhibited the most disease-associated...

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Detalles Bibliográficos
Autores principales:	Rodriguez, Elizabeth, Rallapalli, Pavithra M., Osborne, Amy J., Perkins, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2014
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206863/ https://www.ncbi.nlm.nih.gov/pubmed/25188723 http://dx.doi.org/10.1042/BSR20140117

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