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Mutagenic and antimutagenic effects of Heterotheca inuloides

The antioxidant and hepatoprotective effects of Heterotheca inuloides have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of H. inuloides extracts using the Ames...

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Autores principales: Ruiz-Pérez, Nancy J., Arriaga-Alba, Myriam, Sánchez-Navarrete, Jaime, Camacho-Carranza, Rafael, Hernández-Ojeda, Sandra, Espinosa-Aguirre, Javier J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206868/
https://www.ncbi.nlm.nih.gov/pubmed/25339199
http://dx.doi.org/10.1038/srep06743
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author Ruiz-Pérez, Nancy J.
Arriaga-Alba, Myriam
Sánchez-Navarrete, Jaime
Camacho-Carranza, Rafael
Hernández-Ojeda, Sandra
Espinosa-Aguirre, Javier J.
author_facet Ruiz-Pérez, Nancy J.
Arriaga-Alba, Myriam
Sánchez-Navarrete, Jaime
Camacho-Carranza, Rafael
Hernández-Ojeda, Sandra
Espinosa-Aguirre, Javier J.
author_sort Ruiz-Pérez, Nancy J.
collection PubMed
description The antioxidant and hepatoprotective effects of Heterotheca inuloides have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of H. inuloides extracts using the Ames test. Both, the methanolic and acetonic extracts, were mutagenic in the TA98 but not in TA100 or TA102 strains. On the other hand, the methanolic extract reduced the mutagenicity of norfloxacin, benzo[a]pyrene and 2-aminoanthracene. Quercetin, one of the main components in the methanolic extract, also presented a mutagenic/antimutagenic dual effect and is an inhibitor of Cytochrome P450 (CYP) 1A. The antigenotoxic properties of H. inuloides could be due to the antioxidant properties previously reported and to its CYP inhibitory effect mediated by quercetin. Further studies with in vivo systems will afford information about H. inuloides beneficial and detrimental properties.
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spelling pubmed-42068682014-10-24 Mutagenic and antimutagenic effects of Heterotheca inuloides Ruiz-Pérez, Nancy J. Arriaga-Alba, Myriam Sánchez-Navarrete, Jaime Camacho-Carranza, Rafael Hernández-Ojeda, Sandra Espinosa-Aguirre, Javier J. Sci Rep Article The antioxidant and hepatoprotective effects of Heterotheca inuloides have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of H. inuloides extracts using the Ames test. Both, the methanolic and acetonic extracts, were mutagenic in the TA98 but not in TA100 or TA102 strains. On the other hand, the methanolic extract reduced the mutagenicity of norfloxacin, benzo[a]pyrene and 2-aminoanthracene. Quercetin, one of the main components in the methanolic extract, also presented a mutagenic/antimutagenic dual effect and is an inhibitor of Cytochrome P450 (CYP) 1A. The antigenotoxic properties of H. inuloides could be due to the antioxidant properties previously reported and to its CYP inhibitory effect mediated by quercetin. Further studies with in vivo systems will afford information about H. inuloides beneficial and detrimental properties. Nature Publishing Group 2014-10-23 /pmc/articles/PMC4206868/ /pubmed/25339199 http://dx.doi.org/10.1038/srep06743 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Ruiz-Pérez, Nancy J.
Arriaga-Alba, Myriam
Sánchez-Navarrete, Jaime
Camacho-Carranza, Rafael
Hernández-Ojeda, Sandra
Espinosa-Aguirre, Javier J.
Mutagenic and antimutagenic effects of Heterotheca inuloides
title Mutagenic and antimutagenic effects of Heterotheca inuloides
title_full Mutagenic and antimutagenic effects of Heterotheca inuloides
title_fullStr Mutagenic and antimutagenic effects of Heterotheca inuloides
title_full_unstemmed Mutagenic and antimutagenic effects of Heterotheca inuloides
title_short Mutagenic and antimutagenic effects of Heterotheca inuloides
title_sort mutagenic and antimutagenic effects of heterotheca inuloides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206868/
https://www.ncbi.nlm.nih.gov/pubmed/25339199
http://dx.doi.org/10.1038/srep06743
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