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Mesenchymal stem cells for inducing tolerance in organ transplantation
Organ transplantation is useful for treating the end stage of organ failure. The induction of tolerance to the transplanted organ is essential for its long-term survival. Immunologic tolerance can be induced by immunosuppressive agents and mixed chimerism. Mixed chimerism is a state in which both re...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206979/ https://www.ncbi.nlm.nih.gov/pubmed/25364716 http://dx.doi.org/10.3389/fcell.2014.00008 |
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author | Guo, Kequan Ikehara, Susumu Meng, Xu |
author_facet | Guo, Kequan Ikehara, Susumu Meng, Xu |
author_sort | Guo, Kequan |
collection | PubMed |
description | Organ transplantation is useful for treating the end stage of organ failure. The induction of tolerance to the transplanted organ is essential for its long-term survival. Immunologic tolerance can be induced by immunosuppressive agents and mixed chimerism. Mixed chimerism is a state in which both recipient-and donor-derived blood cells remain in the hematopoietic system after allogeneic hematopoietic stem cells have been transplanted. Mesenchymal stem cells (MSCs), and immune cells such as dendritic cells and T-reg cells play an important role in the induction of tolerance. MSCs secrete cytokines, which modulate the immune response. In particular, they upregulate T-reg cell function and thereby induce tolerance. Intra-bone marrow-bone marrow transplantation recruits both donor-derived HSCs and MSCs, inducing persistent donor-specific tolerance without the use of immunosuppressants. In this review, we summarize the use of MSCs to induce tolerance in organ transplantation. |
format | Online Article Text |
id | pubmed-4206979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42069792014-10-31 Mesenchymal stem cells for inducing tolerance in organ transplantation Guo, Kequan Ikehara, Susumu Meng, Xu Front Cell Dev Biol Cell and Developmental Biology Organ transplantation is useful for treating the end stage of organ failure. The induction of tolerance to the transplanted organ is essential for its long-term survival. Immunologic tolerance can be induced by immunosuppressive agents and mixed chimerism. Mixed chimerism is a state in which both recipient-and donor-derived blood cells remain in the hematopoietic system after allogeneic hematopoietic stem cells have been transplanted. Mesenchymal stem cells (MSCs), and immune cells such as dendritic cells and T-reg cells play an important role in the induction of tolerance. MSCs secrete cytokines, which modulate the immune response. In particular, they upregulate T-reg cell function and thereby induce tolerance. Intra-bone marrow-bone marrow transplantation recruits both donor-derived HSCs and MSCs, inducing persistent donor-specific tolerance without the use of immunosuppressants. In this review, we summarize the use of MSCs to induce tolerance in organ transplantation. Frontiers Media S.A. 2014-03-17 /pmc/articles/PMC4206979/ /pubmed/25364716 http://dx.doi.org/10.3389/fcell.2014.00008 Text en Copyright © 2014 Guo, Ikehara and Meng. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Guo, Kequan Ikehara, Susumu Meng, Xu Mesenchymal stem cells for inducing tolerance in organ transplantation |
title | Mesenchymal stem cells for inducing tolerance in organ transplantation |
title_full | Mesenchymal stem cells for inducing tolerance in organ transplantation |
title_fullStr | Mesenchymal stem cells for inducing tolerance in organ transplantation |
title_full_unstemmed | Mesenchymal stem cells for inducing tolerance in organ transplantation |
title_short | Mesenchymal stem cells for inducing tolerance in organ transplantation |
title_sort | mesenchymal stem cells for inducing tolerance in organ transplantation |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206979/ https://www.ncbi.nlm.nih.gov/pubmed/25364716 http://dx.doi.org/10.3389/fcell.2014.00008 |
work_keys_str_mv | AT guokequan mesenchymalstemcellsforinducingtoleranceinorgantransplantation AT ikeharasusumu mesenchymalstemcellsforinducingtoleranceinorgantransplantation AT mengxu mesenchymalstemcellsforinducingtoleranceinorgantransplantation |