Stem cell transplantation improves aging-related diseases

Aging is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable. The number of patients with age-associated diseases such as type 2 diabetes mellitus (T2DM), osteoporosis, Alzheimer's disease (AD), Parkinson's disease, atherosclerosis, and...

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Detalles Bibliográficos
Autores principales: Ikehara, Susumu, Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206983/
https://www.ncbi.nlm.nih.gov/pubmed/25364723
http://dx.doi.org/10.3389/fcell.2014.00016
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author Ikehara, Susumu
Li, Ming
author_facet Ikehara, Susumu
Li, Ming
author_sort Ikehara, Susumu
collection PubMed
description Aging is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable. The number of patients with age-associated diseases such as type 2 diabetes mellitus (T2DM), osteoporosis, Alzheimer's disease (AD), Parkinson's disease, atherosclerosis, and cancer has increased recently. Aging-related diseases are related to a deficiency of the immune system, which results from an aged thymus and bone marrow cells. Intra bone marrow-bone marrow transplantation (IBM-BMT) is a useful method to treat intractable diseases. This review summarizes findings that IBM-BMT can improve and treat aging-related diseases, including T2DM, osteoporosis and AD, in animal models.
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spelling pubmed-42069832014-10-31 Stem cell transplantation improves aging-related diseases Ikehara, Susumu Li, Ming Front Cell Dev Biol Cell and Developmental Biology Aging is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable. The number of patients with age-associated diseases such as type 2 diabetes mellitus (T2DM), osteoporosis, Alzheimer's disease (AD), Parkinson's disease, atherosclerosis, and cancer has increased recently. Aging-related diseases are related to a deficiency of the immune system, which results from an aged thymus and bone marrow cells. Intra bone marrow-bone marrow transplantation (IBM-BMT) is a useful method to treat intractable diseases. This review summarizes findings that IBM-BMT can improve and treat aging-related diseases, including T2DM, osteoporosis and AD, in animal models. Frontiers Media S.A. 2014-05-02 /pmc/articles/PMC4206983/ /pubmed/25364723 http://dx.doi.org/10.3389/fcell.2014.00016 Text en Copyright © 2014 Ikehara and Li. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ikehara, Susumu
Li, Ming
Stem cell transplantation improves aging-related diseases
title Stem cell transplantation improves aging-related diseases
title_full Stem cell transplantation improves aging-related diseases
title_fullStr Stem cell transplantation improves aging-related diseases
title_full_unstemmed Stem cell transplantation improves aging-related diseases
title_short Stem cell transplantation improves aging-related diseases
title_sort stem cell transplantation improves aging-related diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206983/
https://www.ncbi.nlm.nih.gov/pubmed/25364723
http://dx.doi.org/10.3389/fcell.2014.00016
work_keys_str_mv AT ikeharasusumu stemcelltransplantationimprovesagingrelateddiseases
AT liming stemcelltransplantationimprovesagingrelateddiseases

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