Intractable diseases treated with intra-bone marrow-bone marrow transplantation

Bone marrow transplantation (BMT) is used to treat hematological disorders, autoimmune diseases (ADs) and lymphoid cancers. Intra bone marrow-BMT (IBM-BMT) has been proven to be a powerful strategy for allogeneic BMT due to the rapid hematopoietic recovery and the complete restoration of T cell func...

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Detalles Bibliográficos
Autores principales: Li, Ming, Guo, Kuquan, Ikehara, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206987/
https://www.ncbi.nlm.nih.gov/pubmed/25364755
http://dx.doi.org/10.3389/fcell.2014.00048
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author Li, Ming
Guo, Kuquan
Ikehara, Susumu
author_facet Li, Ming
Guo, Kuquan
Ikehara, Susumu
author_sort Li, Ming
collection PubMed
description Bone marrow transplantation (BMT) is used to treat hematological disorders, autoimmune diseases (ADs) and lymphoid cancers. Intra bone marrow-BMT (IBM-BMT) has been proven to be a powerful strategy for allogeneic BMT due to the rapid hematopoietic recovery and the complete restoration of T cell functions. IBM-BMT not only replaces hematopoietic stem cells (HSCs) but also mesenchymal stromal cells (MSCs). MSCs are multi-potent stem cells that can be isolated from bone marrow (BM), umbilical cord blood (UCB), and adipose tissue. MSCs play an important role in the support of hematopoiesis, and modify and influence the innate and adaptive immune systems. MSCs also differentiate into mesodermal, endodermal and ectodermal lineage cells to repair tissues. This review aims to summarize the functions of BM-derived-MSCs, and the treatment of intractable diseases such as rheumatoid arthritis (RA) and malignant tumors with IBM-BMT.
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spelling pubmed-42069872014-10-31 Intractable diseases treated with intra-bone marrow-bone marrow transplantation Li, Ming Guo, Kuquan Ikehara, Susumu Front Cell Dev Biol Cell and Developmental Biology Bone marrow transplantation (BMT) is used to treat hematological disorders, autoimmune diseases (ADs) and lymphoid cancers. Intra bone marrow-BMT (IBM-BMT) has been proven to be a powerful strategy for allogeneic BMT due to the rapid hematopoietic recovery and the complete restoration of T cell functions. IBM-BMT not only replaces hematopoietic stem cells (HSCs) but also mesenchymal stromal cells (MSCs). MSCs are multi-potent stem cells that can be isolated from bone marrow (BM), umbilical cord blood (UCB), and adipose tissue. MSCs play an important role in the support of hematopoiesis, and modify and influence the innate and adaptive immune systems. MSCs also differentiate into mesodermal, endodermal and ectodermal lineage cells to repair tissues. This review aims to summarize the functions of BM-derived-MSCs, and the treatment of intractable diseases such as rheumatoid arthritis (RA) and malignant tumors with IBM-BMT. Frontiers Media S.A. 2014-09-02 /pmc/articles/PMC4206987/ /pubmed/25364755 http://dx.doi.org/10.3389/fcell.2014.00048 Text en Copyright © 2014 Li, Guo and Ikehara. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Li, Ming
Guo, Kuquan
Ikehara, Susumu
Intractable diseases treated with intra-bone marrow-bone marrow transplantation
title Intractable diseases treated with intra-bone marrow-bone marrow transplantation
title_full Intractable diseases treated with intra-bone marrow-bone marrow transplantation
title_fullStr Intractable diseases treated with intra-bone marrow-bone marrow transplantation
title_full_unstemmed Intractable diseases treated with intra-bone marrow-bone marrow transplantation
title_short Intractable diseases treated with intra-bone marrow-bone marrow transplantation
title_sort intractable diseases treated with intra-bone marrow-bone marrow transplantation
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206987/
https://www.ncbi.nlm.nih.gov/pubmed/25364755
http://dx.doi.org/10.3389/fcell.2014.00048
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