Moonlighting functions of the NRZ (mammalian Dsl1) complex

The yeast Dsl1 complex, which comprises Dsl1, Tip20, and Sec39/Dsl3, has been shown to participate, as a vesicle-tethering complex, in retrograde trafficking from the Golgi apparatus to the endoplasmic reticulum. Its metazoan counterpart NRZ complex, which comprises NAG, RINT1, and ZW10, is also inv...

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Autores principales: Tagaya, Mitsuo, Arasaki, Kohei, Inoue, Hiroki, Kimura, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206994/
https://www.ncbi.nlm.nih.gov/pubmed/25364732
http://dx.doi.org/10.3389/fcell.2014.00025
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author Tagaya, Mitsuo
Arasaki, Kohei
Inoue, Hiroki
Kimura, Hana
author_facet Tagaya, Mitsuo
Arasaki, Kohei
Inoue, Hiroki
Kimura, Hana
author_sort Tagaya, Mitsuo
collection PubMed
description The yeast Dsl1 complex, which comprises Dsl1, Tip20, and Sec39/Dsl3, has been shown to participate, as a vesicle-tethering complex, in retrograde trafficking from the Golgi apparatus to the endoplasmic reticulum. Its metazoan counterpart NRZ complex, which comprises NAG, RINT1, and ZW10, is also involved in Golgi-to-ER retrograde transport, but each component of the complex has diverse cellular functions including endosome-to-Golgi transport, cytokinesis, cell cycle checkpoint, autophagy, and mRNA decay. In this review, we summarize the current knowledge of the metazoan NRZ complex and discuss the “moonlighting” functions and intercorrelation of their subunits.
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spelling pubmed-42069942014-10-31 Moonlighting functions of the NRZ (mammalian Dsl1) complex Tagaya, Mitsuo Arasaki, Kohei Inoue, Hiroki Kimura, Hana Front Cell Dev Biol Cell and Developmental Biology The yeast Dsl1 complex, which comprises Dsl1, Tip20, and Sec39/Dsl3, has been shown to participate, as a vesicle-tethering complex, in retrograde trafficking from the Golgi apparatus to the endoplasmic reticulum. Its metazoan counterpart NRZ complex, which comprises NAG, RINT1, and ZW10, is also involved in Golgi-to-ER retrograde transport, but each component of the complex has diverse cellular functions including endosome-to-Golgi transport, cytokinesis, cell cycle checkpoint, autophagy, and mRNA decay. In this review, we summarize the current knowledge of the metazoan NRZ complex and discuss the “moonlighting” functions and intercorrelation of their subunits. Frontiers Media S.A. 2014-06-11 /pmc/articles/PMC4206994/ /pubmed/25364732 http://dx.doi.org/10.3389/fcell.2014.00025 Text en Copyright © 2014 Tagaya, Arasaki, Inoue and Kimura. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Tagaya, Mitsuo
Arasaki, Kohei
Inoue, Hiroki
Kimura, Hana
Moonlighting functions of the NRZ (mammalian Dsl1) complex
title Moonlighting functions of the NRZ (mammalian Dsl1) complex
title_full Moonlighting functions of the NRZ (mammalian Dsl1) complex
title_fullStr Moonlighting functions of the NRZ (mammalian Dsl1) complex
title_full_unstemmed Moonlighting functions of the NRZ (mammalian Dsl1) complex
title_short Moonlighting functions of the NRZ (mammalian Dsl1) complex
title_sort moonlighting functions of the nrz (mammalian dsl1) complex
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206994/
https://www.ncbi.nlm.nih.gov/pubmed/25364732
http://dx.doi.org/10.3389/fcell.2014.00025
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