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Are MSCs angiogenic cells? New insights on human nestin-positive bone marrow-derived multipotent cells

Recent investigations have made considerable progress in the understanding of tissue regeneration driven by mesenchymal stromal cells (MSCs). Data indicate the anatomical location of MSC as residing in the “perivascular” space of blood vessels dispersed across the whole body. This histological local...

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Autores principales: Pacini, Simone, Petrini, Iacopo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207020/
https://www.ncbi.nlm.nih.gov/pubmed/25364727
http://dx.doi.org/10.3389/fcell.2014.00020
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author Pacini, Simone
Petrini, Iacopo
author_facet Pacini, Simone
Petrini, Iacopo
author_sort Pacini, Simone
collection PubMed
description Recent investigations have made considerable progress in the understanding of tissue regeneration driven by mesenchymal stromal cells (MSCs). Data indicate the anatomical location of MSC as residing in the “perivascular” space of blood vessels dispersed across the whole body. This histological localization suggests that MSCs contribute to the formation of new blood vessels in vivo. Indeed, MSCs can release angiogenic factors and protease to facilitate blood vessel formation and in vitro are able to promote/support angiogenesis. However, the direct differentiation of MCSs into endothelial cells is still matter of debate. Most of the conflicting data might arise from the presence of multiple subtypes of cells with heterogeneous morpho functional features within the MSC cultures. According to this scenario, we hypothesize that the presence of the recently described Mesodermal Progenitor Cells (MPCs) within the MSCs cultures is responsible for their variable angiogenic potential. Indeed, MPCs are Nestin-positive CD31-positive cells exhibiting angiogenic potential that differentiate in MSC upon proper stimuli. The ISCT criteria do not account for the presence of MPC within MSC culture generating confusion in the interpretation of MSC angiogenic potential. In conclusion, the discovery of MPC gives new insight in defining MSC ancestors in human bone marrow, and indicates the tunica intima as a further, and previously overlooked, possible additional source of MSC.
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spelling pubmed-42070202014-10-31 Are MSCs angiogenic cells? New insights on human nestin-positive bone marrow-derived multipotent cells Pacini, Simone Petrini, Iacopo Front Cell Dev Biol Cell and Developmental Biology Recent investigations have made considerable progress in the understanding of tissue regeneration driven by mesenchymal stromal cells (MSCs). Data indicate the anatomical location of MSC as residing in the “perivascular” space of blood vessels dispersed across the whole body. This histological localization suggests that MSCs contribute to the formation of new blood vessels in vivo. Indeed, MSCs can release angiogenic factors and protease to facilitate blood vessel formation and in vitro are able to promote/support angiogenesis. However, the direct differentiation of MCSs into endothelial cells is still matter of debate. Most of the conflicting data might arise from the presence of multiple subtypes of cells with heterogeneous morpho functional features within the MSC cultures. According to this scenario, we hypothesize that the presence of the recently described Mesodermal Progenitor Cells (MPCs) within the MSCs cultures is responsible for their variable angiogenic potential. Indeed, MPCs are Nestin-positive CD31-positive cells exhibiting angiogenic potential that differentiate in MSC upon proper stimuli. The ISCT criteria do not account for the presence of MPC within MSC culture generating confusion in the interpretation of MSC angiogenic potential. In conclusion, the discovery of MPC gives new insight in defining MSC ancestors in human bone marrow, and indicates the tunica intima as a further, and previously overlooked, possible additional source of MSC. Frontiers Media S.A. 2014-05-20 /pmc/articles/PMC4207020/ /pubmed/25364727 http://dx.doi.org/10.3389/fcell.2014.00020 Text en Copyright © 2014 Pacini and Petrini. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Pacini, Simone
Petrini, Iacopo
Are MSCs angiogenic cells? New insights on human nestin-positive bone marrow-derived multipotent cells
title Are MSCs angiogenic cells? New insights on human nestin-positive bone marrow-derived multipotent cells
title_full Are MSCs angiogenic cells? New insights on human nestin-positive bone marrow-derived multipotent cells
title_fullStr Are MSCs angiogenic cells? New insights on human nestin-positive bone marrow-derived multipotent cells
title_full_unstemmed Are MSCs angiogenic cells? New insights on human nestin-positive bone marrow-derived multipotent cells
title_short Are MSCs angiogenic cells? New insights on human nestin-positive bone marrow-derived multipotent cells
title_sort are mscs angiogenic cells? new insights on human nestin-positive bone marrow-derived multipotent cells
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207020/
https://www.ncbi.nlm.nih.gov/pubmed/25364727
http://dx.doi.org/10.3389/fcell.2014.00020
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