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Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection

In this study, we assessed the in vivo behavior and toxicology of nanoscale graphene oxide (NGO) in mice after intravenous injection. The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained i...

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Detalles Bibliográficos
Autores principales: Li, Bo, Zhang, Xiao-Yong, Yang, Jian-Zhong, Zhang, Yu-Jie, Li, Wen-Xin, Fan, Chun-Hai, Huang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207078/
https://www.ncbi.nlm.nih.gov/pubmed/25356071
http://dx.doi.org/10.2147/IJN.S66591
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author Li, Bo
Zhang, Xiao-Yong
Yang, Jian-Zhong
Zhang, Yu-Jie
Li, Wen-Xin
Fan, Chun-Hai
Huang, Qing
author_facet Li, Bo
Zhang, Xiao-Yong
Yang, Jian-Zhong
Zhang, Yu-Jie
Li, Wen-Xin
Fan, Chun-Hai
Huang, Qing
author_sort Li, Bo
collection PubMed
description In this study, we assessed the in vivo behavior and toxicology of nanoscale graphene oxide (NGO) in mice after intravenous injection. The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained in the liver, lung, and spleen. Retention in the lung is partially due to NGO aggregation. The PEG coating reduces the retention of NGO in the liver, lung, and spleen and promotes the clearance of NGO from these organs, but NGO and NGO-PEG are still present after 3 months. The PEG coating effectively reduces the early weight loss caused by NGO and alleviates NGO-induced acute tissue injuries, which can include damage to the liver, lung, and kidney, and chronic hepatic and lung fibrosis.
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spelling pubmed-42070782014-10-29 Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection Li, Bo Zhang, Xiao-Yong Yang, Jian-Zhong Zhang, Yu-Jie Li, Wen-Xin Fan, Chun-Hai Huang, Qing Int J Nanomedicine Original Research In this study, we assessed the in vivo behavior and toxicology of nanoscale graphene oxide (NGO) in mice after intravenous injection. The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained in the liver, lung, and spleen. Retention in the lung is partially due to NGO aggregation. The PEG coating reduces the retention of NGO in the liver, lung, and spleen and promotes the clearance of NGO from these organs, but NGO and NGO-PEG are still present after 3 months. The PEG coating effectively reduces the early weight loss caused by NGO and alleviates NGO-induced acute tissue injuries, which can include damage to the liver, lung, and kidney, and chronic hepatic and lung fibrosis. Dove Medical Press 2014-10-08 /pmc/articles/PMC4207078/ /pubmed/25356071 http://dx.doi.org/10.2147/IJN.S66591 Text en © 2014 Li et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Li, Bo
Zhang, Xiao-Yong
Yang, Jian-Zhong
Zhang, Yu-Jie
Li, Wen-Xin
Fan, Chun-Hai
Huang, Qing
Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection
title Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection
title_full Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection
title_fullStr Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection
title_full_unstemmed Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection
title_short Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection
title_sort influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207078/
https://www.ncbi.nlm.nih.gov/pubmed/25356071
http://dx.doi.org/10.2147/IJN.S66591
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