Cargando…
Surgical Ligation on Significant Patent Ductus Arteriosus in Very Low Birth Weight Infants: Comparison between Early and Late Ligations
BACKGROUND: We aimed to evaluate the efficacy and safety of early surgical ligation (within 15 days of age) over late surgical ligation (after 15 days of age) by a comparative analysis of very low birth weight (VLBW) infants undergoing surgical correction for symptomatic patent ductus arteriosus (PD...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Thoracic and Cardiovascular Surgery
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207104/ https://www.ncbi.nlm.nih.gov/pubmed/25346899 http://dx.doi.org/10.5090/kjtcs.2014.47.5.444 |
_version_ | 1782340922725367808 |
---|---|
author | Lee, Jun Ho Ro, Sun Kyun Lee, Hyun Ju Park, Hyun Kyung Chung, Won-Sang Kim, Young Hak Kang, Jeong Ho Kim, Hyuck |
author_facet | Lee, Jun Ho Ro, Sun Kyun Lee, Hyun Ju Park, Hyun Kyung Chung, Won-Sang Kim, Young Hak Kang, Jeong Ho Kim, Hyuck |
author_sort | Lee, Jun Ho |
collection | PubMed |
description | BACKGROUND: We aimed to evaluate the efficacy and safety of early surgical ligation (within 15 days of age) over late surgical ligation (after 15 days of age) by a comparative analysis of very low birth weight (VLBW) infants undergoing surgical correction for symptomatic patent ductus arteriosus (PDA) over the course of 6 years in our hospital. METHODS: We retrospectively reviewed all the medical records in the neonatal intensive care unit at Hanyang University Seoul Hospital, from March 2007 to May 2013, to identify VLBW infants (< 1,500 g) who underwent surgical PDA ligation. RESULTS: The gestational age (GA) in the late ligation (LL) group was significantly younger than in the early ligation (EL) group (p=0.010). The other baseline characteristics and preoperative conditions did not differ significantly between the two groups. The intubation period before surgery (p < 0.001) and the age at surgery (p < 0.001) were significantly different. The postoperative clinical outcomes of the study patients, including major morbidity and mortality, are summarized. There were no significant differences in bronchopulmonary dysplasia, sepsis, or mortality between the EL and the LL groups. However, the LL group was significantly associated with an increased risk of necrotizing enterocolitis (p=0.037) and with a prolonged duration of the total parenteral nutrition (p=0.046) after adjusting for GA. CONCLUSION: Early surgical ligation for the treatment of PDA that failed to close after medical treatment or in cases contraindicated for medical treatment might be desirable to reduce the incidence of necrotizing enterocolitis and to alleviate feeding intolerance in preterm infants. |
format | Online Article Text |
id | pubmed-4207104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Society for Thoracic and Cardiovascular Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-42071042014-10-24 Surgical Ligation on Significant Patent Ductus Arteriosus in Very Low Birth Weight Infants: Comparison between Early and Late Ligations Lee, Jun Ho Ro, Sun Kyun Lee, Hyun Ju Park, Hyun Kyung Chung, Won-Sang Kim, Young Hak Kang, Jeong Ho Kim, Hyuck Korean J Thorac Cardiovasc Surg Clinical Research BACKGROUND: We aimed to evaluate the efficacy and safety of early surgical ligation (within 15 days of age) over late surgical ligation (after 15 days of age) by a comparative analysis of very low birth weight (VLBW) infants undergoing surgical correction for symptomatic patent ductus arteriosus (PDA) over the course of 6 years in our hospital. METHODS: We retrospectively reviewed all the medical records in the neonatal intensive care unit at Hanyang University Seoul Hospital, from March 2007 to May 2013, to identify VLBW infants (< 1,500 g) who underwent surgical PDA ligation. RESULTS: The gestational age (GA) in the late ligation (LL) group was significantly younger than in the early ligation (EL) group (p=0.010). The other baseline characteristics and preoperative conditions did not differ significantly between the two groups. The intubation period before surgery (p < 0.001) and the age at surgery (p < 0.001) were significantly different. The postoperative clinical outcomes of the study patients, including major morbidity and mortality, are summarized. There were no significant differences in bronchopulmonary dysplasia, sepsis, or mortality between the EL and the LL groups. However, the LL group was significantly associated with an increased risk of necrotizing enterocolitis (p=0.037) and with a prolonged duration of the total parenteral nutrition (p=0.046) after adjusting for GA. CONCLUSION: Early surgical ligation for the treatment of PDA that failed to close after medical treatment or in cases contraindicated for medical treatment might be desirable to reduce the incidence of necrotizing enterocolitis and to alleviate feeding intolerance in preterm infants. The Korean Society for Thoracic and Cardiovascular Surgery 2014-10 2014-10-05 /pmc/articles/PMC4207104/ /pubmed/25346899 http://dx.doi.org/10.5090/kjtcs.2014.47.5.444 Text en Copyright © 2014 by The Korean Society for Thoracic and Cardiovascular Surgery. All rights Reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Research Lee, Jun Ho Ro, Sun Kyun Lee, Hyun Ju Park, Hyun Kyung Chung, Won-Sang Kim, Young Hak Kang, Jeong Ho Kim, Hyuck Surgical Ligation on Significant Patent Ductus Arteriosus in Very Low Birth Weight Infants: Comparison between Early and Late Ligations |
title | Surgical Ligation on Significant Patent Ductus Arteriosus in Very Low Birth Weight Infants: Comparison between Early and Late Ligations |
title_full | Surgical Ligation on Significant Patent Ductus Arteriosus in Very Low Birth Weight Infants: Comparison between Early and Late Ligations |
title_fullStr | Surgical Ligation on Significant Patent Ductus Arteriosus in Very Low Birth Weight Infants: Comparison between Early and Late Ligations |
title_full_unstemmed | Surgical Ligation on Significant Patent Ductus Arteriosus in Very Low Birth Weight Infants: Comparison between Early and Late Ligations |
title_short | Surgical Ligation on Significant Patent Ductus Arteriosus in Very Low Birth Weight Infants: Comparison between Early and Late Ligations |
title_sort | surgical ligation on significant patent ductus arteriosus in very low birth weight infants: comparison between early and late ligations |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207104/ https://www.ncbi.nlm.nih.gov/pubmed/25346899 http://dx.doi.org/10.5090/kjtcs.2014.47.5.444 |
work_keys_str_mv | AT leejunho surgicalligationonsignificantpatentductusarteriosusinverylowbirthweightinfantscomparisonbetweenearlyandlateligations AT rosunkyun surgicalligationonsignificantpatentductusarteriosusinverylowbirthweightinfantscomparisonbetweenearlyandlateligations AT leehyunju surgicalligationonsignificantpatentductusarteriosusinverylowbirthweightinfantscomparisonbetweenearlyandlateligations AT parkhyunkyung surgicalligationonsignificantpatentductusarteriosusinverylowbirthweightinfantscomparisonbetweenearlyandlateligations AT chungwonsang surgicalligationonsignificantpatentductusarteriosusinverylowbirthweightinfantscomparisonbetweenearlyandlateligations AT kimyounghak surgicalligationonsignificantpatentductusarteriosusinverylowbirthweightinfantscomparisonbetweenearlyandlateligations AT kangjeongho surgicalligationonsignificantpatentductusarteriosusinverylowbirthweightinfantscomparisonbetweenearlyandlateligations AT kimhyuck surgicalligationonsignificantpatentductusarteriosusinverylowbirthweightinfantscomparisonbetweenearlyandlateligations |