Cycloadditions of Cyclohexynes and Cyclopentyne

[Image: see text] We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described. The observed regioselectivities are expla...

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Detalles Bibliográficos
Autores principales: Medina, Jose M., McMahon, Travis C., Jiménez-Osés, Gonzalo, Houk, K. N., Garg, Neil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207212/
https://www.ncbi.nlm.nih.gov/pubmed/25283710
http://dx.doi.org/10.1021/ja508635v
Descripción
Sumario:[Image: see text] We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described. The observed regioselectivities are explained by the distortion/interaction model.

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