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Cycloadditions of Cyclohexynes and Cyclopentyne
[Image: see text] We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described. The observed regioselectivities are expla...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207212/ https://www.ncbi.nlm.nih.gov/pubmed/25283710 http://dx.doi.org/10.1021/ja508635v |
| _version_ | 1782340936914698240 |
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| author | Medina, Jose M. McMahon, Travis C. Jiménez-Osés, Gonzalo Houk, K. N. Garg, Neil K. |
| author_facet | Medina, Jose M. McMahon, Travis C. Jiménez-Osés, Gonzalo Houk, K. N. Garg, Neil K. |
| author_sort | Medina, Jose M. |
| collection | PubMed |
| description | [Image: see text] We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described. The observed regioselectivities are explained by the distortion/interaction model. |
| format | Online Article Text |
| id | pubmed-4207212 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | American Chemical
Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-42072122015-10-05 Cycloadditions of Cyclohexynes and Cyclopentyne Medina, Jose M. McMahon, Travis C. Jiménez-Osés, Gonzalo Houk, K. N. Garg, Neil K. J Am Chem Soc [Image: see text] We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described. The observed regioselectivities are explained by the distortion/interaction model. American Chemical Society 2014-10-05 2014-10-22 /pmc/articles/PMC4207212/ /pubmed/25283710 http://dx.doi.org/10.1021/ja508635v Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) |
| spellingShingle | Medina, Jose M. McMahon, Travis C. Jiménez-Osés, Gonzalo Houk, K. N. Garg, Neil K. Cycloadditions of Cyclohexynes and Cyclopentyne |
| title | Cycloadditions
of Cyclohexynes and Cyclopentyne |
| title_full | Cycloadditions
of Cyclohexynes and Cyclopentyne |
| title_fullStr | Cycloadditions
of Cyclohexynes and Cyclopentyne |
| title_full_unstemmed | Cycloadditions
of Cyclohexynes and Cyclopentyne |
| title_short | Cycloadditions
of Cyclohexynes and Cyclopentyne |
| title_sort | cycloadditions
of cyclohexynes and cyclopentyne |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207212/ https://www.ncbi.nlm.nih.gov/pubmed/25283710 http://dx.doi.org/10.1021/ja508635v |
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