Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome

Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) ar...

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Autores principales: Deka, Nabajyoti, Bajare, Swapnil, Anthony, Jessy, Nair, Amrutha, Damre, Anagha, Patel, Dharmeshkumar, B-Rao, Chandrika, Sivaramakrishnan, H., Mutt, Shivaprakash Jagalur, Wilankar, Chandan, Marita, Rosalind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207384/
https://www.ncbi.nlm.nih.gov/pubmed/25374688
http://dx.doi.org/10.1155/2013/201580
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author Deka, Nabajyoti
Bajare, Swapnil
Anthony, Jessy
Nair, Amrutha
Damre, Anagha
Patel, Dharmeshkumar
B-Rao, Chandrika
Sivaramakrishnan, H.
Mutt, Shivaprakash Jagalur
Wilankar, Chandan
Marita, Rosalind
author_facet Deka, Nabajyoti
Bajare, Swapnil
Anthony, Jessy
Nair, Amrutha
Damre, Anagha
Patel, Dharmeshkumar
B-Rao, Chandrika
Sivaramakrishnan, H.
Mutt, Shivaprakash Jagalur
Wilankar, Chandan
Marita, Rosalind
author_sort Deka, Nabajyoti
collection PubMed
description Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.
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spelling pubmed-42073842014-11-05 Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome Deka, Nabajyoti Bajare, Swapnil Anthony, Jessy Nair, Amrutha Damre, Anagha Patel, Dharmeshkumar B-Rao, Chandrika Sivaramakrishnan, H. Mutt, Shivaprakash Jagalur Wilankar, Chandan Marita, Rosalind Int J Med Chem Research Article Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance. Hindawi Publishing Corporation 2013 2013-12-22 /pmc/articles/PMC4207384/ /pubmed/25374688 http://dx.doi.org/10.1155/2013/201580 Text en Copyright © 2013 Nabajyoti Deka et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Deka, Nabajyoti
Bajare, Swapnil
Anthony, Jessy
Nair, Amrutha
Damre, Anagha
Patel, Dharmeshkumar
B-Rao, Chandrika
Sivaramakrishnan, H.
Mutt, Shivaprakash Jagalur
Wilankar, Chandan
Marita, Rosalind
Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome
title Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome
title_full Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome
title_fullStr Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome
title_full_unstemmed Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome
title_short Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome
title_sort synthesis of n-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives for the treatment of metabolic syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207384/
https://www.ncbi.nlm.nih.gov/pubmed/25374688
http://dx.doi.org/10.1155/2013/201580
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