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Trends in Incidence of Type 1 Diabetes Among Non-Hispanic White Youth in the U.S., 2002–2009

The SEARCH for Diabetes in Youth Study prospectively identified youth aged <20 years with physician-diagnosed diabetes. Annual type 1 diabetes (T1D) incidence per 100,000 person-years (95% CI) overall, by age-group, and by sex were calculated for at-risk non-Hispanic white (NHW) youth from 2002 t...

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Autores principales: Lawrence, Jean M., Imperatore, Giuseppina, Dabelea, Dana, Mayer-Davis, Elizabeth J., Linder, Barbara, Saydah, Sharon, Klingensmith, Georgeanna J., Dolan, Lawrence, Standiford, Debra A., Pihoker, Catherine, Pettitt, David J., Talton, Jennifer W., Thomas, Joan, Bell, Ronny A., D’Agostino, Ralph B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207387/
https://www.ncbi.nlm.nih.gov/pubmed/24898146
http://dx.doi.org/10.2337/db13-1891
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author Lawrence, Jean M.
Imperatore, Giuseppina
Dabelea, Dana
Mayer-Davis, Elizabeth J.
Linder, Barbara
Saydah, Sharon
Klingensmith, Georgeanna J.
Dolan, Lawrence
Standiford, Debra A.
Pihoker, Catherine
Pettitt, David J.
Talton, Jennifer W.
Thomas, Joan
Bell, Ronny A.
D’Agostino, Ralph B.
author_facet Lawrence, Jean M.
Imperatore, Giuseppina
Dabelea, Dana
Mayer-Davis, Elizabeth J.
Linder, Barbara
Saydah, Sharon
Klingensmith, Georgeanna J.
Dolan, Lawrence
Standiford, Debra A.
Pihoker, Catherine
Pettitt, David J.
Talton, Jennifer W.
Thomas, Joan
Bell, Ronny A.
D’Agostino, Ralph B.
author_sort Lawrence, Jean M.
collection PubMed
description The SEARCH for Diabetes in Youth Study prospectively identified youth aged <20 years with physician-diagnosed diabetes. Annual type 1 diabetes (T1D) incidence per 100,000 person-years (95% CI) overall, by age-group, and by sex were calculated for at-risk non-Hispanic white (NHW) youth from 2002 through 2009. Joinpoint and Poisson regression models were used to test for temporal trends. The age- and sex-adjusted incidence of T1D increased from 24.4/100,000 (95% CI 23.9–24.8) in 2002 to 27.4/100,000 (26.9–27.9) in 2009 (P for trend = 0.0008). The relative annual increase in T1D incidence was 2.72% (1.18–4.28) per year; 2.84% (1.12–4.58) per year for males and 2.57% (0.68–4.51) per year for females. After adjustment for sex, significant increases were found for youth aged 5–9 years (P = 0.0023), 10–14 years (P = 0.0008), and 15–19 years (P = 0.004) but not among 0–4-year-olds (P = 0.1862). Mean age at diagnosis did not change. The SEARCH study demonstrated a significant increase in the incidence of T1D among NHW youth from 2002 through 2009 overall and in all but the youngest age-group. Continued surveillance of T1D in U.S. youth to identify future trends in T1D incidence and to plan for health care delivery is warranted.
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spelling pubmed-42073872015-11-01 Trends in Incidence of Type 1 Diabetes Among Non-Hispanic White Youth in the U.S., 2002–2009 Lawrence, Jean M. Imperatore, Giuseppina Dabelea, Dana Mayer-Davis, Elizabeth J. Linder, Barbara Saydah, Sharon Klingensmith, Georgeanna J. Dolan, Lawrence Standiford, Debra A. Pihoker, Catherine Pettitt, David J. Talton, Jennifer W. Thomas, Joan Bell, Ronny A. D’Agostino, Ralph B. Diabetes Complications The SEARCH for Diabetes in Youth Study prospectively identified youth aged <20 years with physician-diagnosed diabetes. Annual type 1 diabetes (T1D) incidence per 100,000 person-years (95% CI) overall, by age-group, and by sex were calculated for at-risk non-Hispanic white (NHW) youth from 2002 through 2009. Joinpoint and Poisson regression models were used to test for temporal trends. The age- and sex-adjusted incidence of T1D increased from 24.4/100,000 (95% CI 23.9–24.8) in 2002 to 27.4/100,000 (26.9–27.9) in 2009 (P for trend = 0.0008). The relative annual increase in T1D incidence was 2.72% (1.18–4.28) per year; 2.84% (1.12–4.58) per year for males and 2.57% (0.68–4.51) per year for females. After adjustment for sex, significant increases were found for youth aged 5–9 years (P = 0.0023), 10–14 years (P = 0.0008), and 15–19 years (P = 0.004) but not among 0–4-year-olds (P = 0.1862). Mean age at diagnosis did not change. The SEARCH study demonstrated a significant increase in the incidence of T1D among NHW youth from 2002 through 2009 overall and in all but the youngest age-group. Continued surveillance of T1D in U.S. youth to identify future trends in T1D incidence and to plan for health care delivery is warranted. American Diabetes Association 2014-11 2014-10-13 /pmc/articles/PMC4207387/ /pubmed/24898146 http://dx.doi.org/10.2337/db13-1891 Text en © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
spellingShingle Complications
Lawrence, Jean M.
Imperatore, Giuseppina
Dabelea, Dana
Mayer-Davis, Elizabeth J.
Linder, Barbara
Saydah, Sharon
Klingensmith, Georgeanna J.
Dolan, Lawrence
Standiford, Debra A.
Pihoker, Catherine
Pettitt, David J.
Talton, Jennifer W.
Thomas, Joan
Bell, Ronny A.
D’Agostino, Ralph B.
Trends in Incidence of Type 1 Diabetes Among Non-Hispanic White Youth in the U.S., 2002–2009
title Trends in Incidence of Type 1 Diabetes Among Non-Hispanic White Youth in the U.S., 2002–2009
title_full Trends in Incidence of Type 1 Diabetes Among Non-Hispanic White Youth in the U.S., 2002–2009
title_fullStr Trends in Incidence of Type 1 Diabetes Among Non-Hispanic White Youth in the U.S., 2002–2009
title_full_unstemmed Trends in Incidence of Type 1 Diabetes Among Non-Hispanic White Youth in the U.S., 2002–2009
title_short Trends in Incidence of Type 1 Diabetes Among Non-Hispanic White Youth in the U.S., 2002–2009
title_sort trends in incidence of type 1 diabetes among non-hispanic white youth in the u.s., 2002–2009
topic Complications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207387/
https://www.ncbi.nlm.nih.gov/pubmed/24898146
http://dx.doi.org/10.2337/db13-1891
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