Cargando…

Molecular Signatures Differentiate Immune States in Type 1 Diabetic Families

Mechanisms associated with type 1 diabetes (T1D) development remain incompletely defined. Using a sensitive array-based bioassay where patient plasma is used to induce transcriptional responses in healthy leukocytes, we previously reported disease-specific, partially interleukin (IL)-1−dependent sig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yi-Guang, Cabrera, Susanne M., Jia, Shuang, Kaldunski, Mary L., Kramer, Joanna, Cheong, Sami, Geoffrey, Rhonda, Roethle, Mark F., Woodliff, Jeffrey E., Greenbaum, Carla J., Wang, Xujing, Hessner, Martin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207392/ https://www.ncbi.nlm.nih.gov/pubmed/24760139 http://dx.doi.org/10.2337/db14-0214

Ejemplares similares

Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study
por: Karabegović, Irma, et al.
Publicado: (2022)

Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations
por: Chen, Brian H., et al.
Publicado: (2016)

Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes
por: Gudmundsdottir, Valborg, et al.
Publicado: (2020)

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study
por: Slieker, Roderick C., et al.
Publicado: (2021)

A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures
por: Varshney, Arushi, et al.
Publicado: (2021)

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes
por: Ferreira, Ricardo C., et al.
Publicado: (2014)

Haptoglobin 1-1 Genotype Modulates the Association of Glycemic Control With Hippocampal Volume in Elderly Individuals With Type 2 Diabetes
por: Livny, Abigail, et al.
Publicado: (2017)

A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts
por: Nogal, Ana, et al.
Publicado: (2023)

Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells
por: Carrasco, Manuel, et al.
Publicado: (2022)

Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model With Impaired Incretin Function and Reduced β-Cell Mass
por: Renner, Simone, et al.
Publicado: (2012)

Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program
por: Walford, Geoffrey A., et al.
Publicado: (2016)

Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish
por: Axton, Elizabeth R, et al.
Publicado: (2019)

Zinc-Associated Variant in SLC30A8 Gene Interacts With Gestational Weight Gain on Postpartum Glycemic Changes: A Longitudinal Study in Women With Prior Gestational Diabetes Mellitus
por: Wang, Tiange, et al.
Publicado: (2016)

Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets
por: Travers, Mary E., et al.
Publicado: (2013)

Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome
por: Zhu, Jing, et al.
Publicado: (2021)

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes
por: Howson, Joanna M.M., et al.
Publicado: (2012)

Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition(1)(2)(3)
por: Di Giovanni, Valeria, et al.
Publicado: (2016)

Metabolic Footprinting of Fermented Milk Consumption in Serum of Healthy Men
por: Pimentel, Grégory, et al.
Publicado: (2018)

DHA Supplementation Attenuates Inflammation-Associated Gene Expression in the Mammary Gland of Lactating Mothers Who Deliver Preterm
por: Adams, Joselyn M, et al.
Publicado: (2022)

Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors
por: Merino, Jordi, et al.
Publicado: (2020)

Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans
por: Sharma, Neeraj K., et al.
Publicado: (2019)

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children(1)(2)(3)
por: Lee, Sun Eun, et al.
Publicado: (2017)

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling
por: Roberts, Geoffrey P., et al.
Publicado: (2019)

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes
por: Teumer, Alexander, et al.
Publicado: (2016)

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
por: Wood, Andrew R., et al.
Publicado: (2017)

The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium
por: Srinivasan, Shylaja, et al.
Publicado: (2021)

Identification of Milk and Cheese Intake Biomarkers in Healthy Adults Reveals High Interindividual Variability of Lewis System–Related Oligosaccharides
por: Pimentel, Grégory, et al.
Publicado: (2020)

Urine Metabolite Profiles and Nutrient Intake Based on 4-Day Weighed Food Diary in Habitual Vegans, Vegetarians, and Omnivores
por: Lindqvist, Helen M, et al.
Publicado: (2020)

Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles
por: Noordam, Raymond, et al.
Publicado: (2021)

Genome-Wide Association Study Identifies Genetic Loci Associated With Fat Cell Number and Overlap With Genetic Risk Loci for Type 2 Diabetes
por: Kulyté, Agné, et al.
Publicado: (2022)

In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes–Associated Single Nucleotide Polymorphisms
por: Eufrásio, Ana, et al.
Publicado: (2020)

Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes
por: Brorsson, Caroline A., et al.
Publicado: (2015)

TXNIP DNA methylation is associated with glycemic control over 28 years in type 1 diabetes: findings from the Pittsburgh Epidemiology of Diabetes Complications (EDC) study
por: Miller, Rachel G, et al.
Publicado: (2023)

Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
por: Marzelli, Matthew J., et al.
Publicado: (2014)

Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study
por: Sobrin, Lucia, et al.
Publicado: (2017)

Dimethylglycine Deficiency and the Development of Diabetes
por: Magnusson, Martin, et al.
Publicado: (2015)

Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study
por: Loomis, Stephanie J., et al.
Publicado: (2018)

Multiple HLA Epitopes Contribute to Type 1 Diabetes Susceptibility
por: Roark, Christina L., et al.
Publicado: (2014)

Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men
por: Stančáková, Alena, et al.
Publicado: (2012)

Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank
por: Klimentidis, Yann C., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ugq3drn9959ffo8onco08lf891