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Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice

Elevated reactive oxygen species (ROS) are linked to insulin resistance and islet dysfunction. Manganese superoxide dismutase (SOD2) is a primary defense against mitochondrial oxidative stress. To test the hypothesis that heterozygous SOD2 deletion impairs glucose-stimulated insulin secretion (GSIS)...

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Detalles Bibliográficos
Autores principales:	Kang, Li, Dai, Chunhua, Lustig, Mary E., Bonner, Jeffrey S., Mayes, Wesley H., Mokshagundam, Shilpa, James, Freyja D., Thompson, Courtney S., Lin, Chien-Te, Perry, Christopher G.R., Anderson, Ethan J., Neufer, P. Darrell, Wasserman, David H., Powers, Alvin C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207395/ https://www.ncbi.nlm.nih.gov/pubmed/24947366 http://dx.doi.org/10.2337/db13-1845

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