A Novel Inhibitor of Mammalian Triosephosphate Isomerase Found by an In Silico Approach

Triosephosphate isomerase (TIM) is an essential, highly conserved component of glycolysis. Tumors are often dependent on glycolysis for energy and metabolite production (the Warburg effect). Glycolysis inhibitors thus show promise as cancer treatments. TIM inhibition, unlike inhibition of other glyc...

Descripción completa

Detalles Bibliográficos
Autores principales: Marsh, Lorraine, Shah, Kaushal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207401/
https://www.ncbi.nlm.nih.gov/pubmed/25383217
http://dx.doi.org/10.1155/2014/469125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207401/
https://www.ncbi.nlm.nih.gov/pubmed/25383217
http://dx.doi.org/10.1155/2014/469125

Ejemplares similares