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A Novel Inhibitor of Mammalian Triosephosphate Isomerase Found by an In Silico Approach
Triosephosphate isomerase (TIM) is an essential, highly conserved component of glycolysis. Tumors are often dependent on glycolysis for energy and metabolite production (the Warburg effect). Glycolysis inhibitors thus show promise as cancer treatments. TIM inhibition, unlike inhibition of other glyc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207401/ https://www.ncbi.nlm.nih.gov/pubmed/25383217 http://dx.doi.org/10.1155/2014/469125 |