Docking Studies and Biological Activity of Fosinopril Analogs

The purpose of the present study was to determine the angiotensin-I converting enzyme inhibitory activity of few novel Fosinopril derivatives which were predicted to possess better ACE inhibitory activity and lesser side effects than the existing drug molecule. In vitro study was carried out to dete...

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Autores principales: Choudary, Jayant, Kini, Suvarna G., Ranganath Pai Karkala, Sreedhara, Mubeen, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207403/
https://www.ncbi.nlm.nih.gov/pubmed/25383221
http://dx.doi.org/10.1155/2014/721834
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author Choudary, Jayant
Kini, Suvarna G.
Ranganath Pai Karkala, Sreedhara
Mubeen, Muhammad
author_facet Choudary, Jayant
Kini, Suvarna G.
Ranganath Pai Karkala, Sreedhara
Mubeen, Muhammad
author_sort Choudary, Jayant
collection PubMed
description The purpose of the present study was to determine the angiotensin-I converting enzyme inhibitory activity of few novel Fosinopril derivatives which were predicted to possess better ACE inhibitory activity and lesser side effects than the existing drug molecule. In vitro study was carried out to determine ACE inhibitory activity of six different Fosinopril analogs by spectrophotometric assay procedure. Analog A2 showed the highest activity compared to other analogs and as well as Fosinopril itself. Docking studies of the compounds were done with the help of VLife MDS 3.0 software using GRIP batch docking method to find out which derivative had a better docking with ACE. The compounds which showed the highest negative score in docking have also exhibited good ACE inhibitory activity.
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spelling pubmed-42074032014-11-09 Docking Studies and Biological Activity of Fosinopril Analogs Choudary, Jayant Kini, Suvarna G. Ranganath Pai Karkala, Sreedhara Mubeen, Muhammad Int J Med Chem Research Article The purpose of the present study was to determine the angiotensin-I converting enzyme inhibitory activity of few novel Fosinopril derivatives which were predicted to possess better ACE inhibitory activity and lesser side effects than the existing drug molecule. In vitro study was carried out to determine ACE inhibitory activity of six different Fosinopril analogs by spectrophotometric assay procedure. Analog A2 showed the highest activity compared to other analogs and as well as Fosinopril itself. Docking studies of the compounds were done with the help of VLife MDS 3.0 software using GRIP batch docking method to find out which derivative had a better docking with ACE. The compounds which showed the highest negative score in docking have also exhibited good ACE inhibitory activity. Hindawi Publishing Corporation 2014 2014-07-06 /pmc/articles/PMC4207403/ /pubmed/25383221 http://dx.doi.org/10.1155/2014/721834 Text en Copyright © 2014 Jayant Choudary et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Choudary, Jayant
Kini, Suvarna G.
Ranganath Pai Karkala, Sreedhara
Mubeen, Muhammad
Docking Studies and Biological Activity of Fosinopril Analogs
title Docking Studies and Biological Activity of Fosinopril Analogs
title_full Docking Studies and Biological Activity of Fosinopril Analogs
title_fullStr Docking Studies and Biological Activity of Fosinopril Analogs
title_full_unstemmed Docking Studies and Biological Activity of Fosinopril Analogs
title_short Docking Studies and Biological Activity of Fosinopril Analogs
title_sort docking studies and biological activity of fosinopril analogs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207403/
https://www.ncbi.nlm.nih.gov/pubmed/25383221
http://dx.doi.org/10.1155/2014/721834
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