Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles

A new series of 2-pyrazolin-1-ylthiazoles 8a–d and 13–16 was synthesized by cyclization of N-thiocarboxamide-2-pyrazoline with different haloketones and 2,3-dichloroquinoxaline. The structures of the new compounds were confirmed by elemental analyses as well as NMR, IR, and mass spectral data. The n...

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Autores principales: Mohamed, Hanan A., Abdel-Latif, Ehab, Abdel-Wahab, Bakr F., Awad, Ghada E. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207413/
https://www.ncbi.nlm.nih.gov/pubmed/25379293
http://dx.doi.org/10.1155/2013/986536
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author Mohamed, Hanan A.
Abdel-Latif, Ehab
Abdel-Wahab, Bakr F.
Awad, Ghada E. A.
author_facet Mohamed, Hanan A.
Abdel-Latif, Ehab
Abdel-Wahab, Bakr F.
Awad, Ghada E. A.
author_sort Mohamed, Hanan A.
collection PubMed
description A new series of 2-pyrazolin-1-ylthiazoles 8a–d and 13–16 was synthesized by cyclization of N-thiocarboxamide-2-pyrazoline with different haloketones and 2,3-dichloroquinoxaline. The structures of the new compounds were confirmed by elemental analyses as well as NMR, IR, and mass spectral data. The newly synthesized compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration (MIC) against most of test organisms was performed. Amongst the tested ones, compound 8c displayed excellent antimicrobial activity.
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spelling pubmed-42074132014-11-06 Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles Mohamed, Hanan A. Abdel-Latif, Ehab Abdel-Wahab, Bakr F. Awad, Ghada E. A. Int J Med Chem Research Article A new series of 2-pyrazolin-1-ylthiazoles 8a–d and 13–16 was synthesized by cyclization of N-thiocarboxamide-2-pyrazoline with different haloketones and 2,3-dichloroquinoxaline. The structures of the new compounds were confirmed by elemental analyses as well as NMR, IR, and mass spectral data. The newly synthesized compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration (MIC) against most of test organisms was performed. Amongst the tested ones, compound 8c displayed excellent antimicrobial activity. Hindawi Publishing Corporation 2013 2013-09-11 /pmc/articles/PMC4207413/ /pubmed/25379293 http://dx.doi.org/10.1155/2013/986536 Text en Copyright © 2013 Hanan A. Mohamed et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mohamed, Hanan A.
Abdel-Latif, Ehab
Abdel-Wahab, Bakr F.
Awad, Ghada E. A.
Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles
title Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles
title_full Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles
title_fullStr Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles
title_full_unstemmed Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles
title_short Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles
title_sort novel antimicrobial agents: fluorinated 2-(3-(benzofuran-2-yl) pyrazol-1-yl)thiazoles
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207413/
https://www.ncbi.nlm.nih.gov/pubmed/25379293
http://dx.doi.org/10.1155/2013/986536
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