Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones

Novel substituted chromenopyridones (3a–j and 6a–d) were synthesized and evaluated in vitro for the cytotoxic activity against various human cancer cell lines such as prostate (PC-3), breast (MCF-7), CNS (IMR-32), cervix (Hela), and liver (Hep-G2). preliminary cytotoxic screening showed that all the...

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Detalles Bibliográficos
Autores principales: Singh, Balwinder, Sharma, Vishal, Singh, Gagandeep, Kumar, Rakesh, Arora, Saroj, Ishar, Mohan Paul Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207455/
https://www.ncbi.nlm.nih.gov/pubmed/25379292
http://dx.doi.org/10.1155/2013/984329
Descripción
Sumario:Novel substituted chromenopyridones (3a–j and 6a–d) were synthesized and evaluated in vitro for the cytotoxic activity against various human cancer cell lines such as prostate (PC-3), breast (MCF-7), CNS (IMR-32), cervix (Hela), and liver (Hep-G2). preliminary cytotoxic screening showed that all the compounds possess a good to moderate inhibitory activity against various cancer cell lines. Particularly, compound 6b bearing allyl moiety displayed a significant cytotoxic potential in comparison to standard drugs.

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