Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones

Novel substituted chromenopyridones (3a–j and 6a–d) were synthesized and evaluated in vitro for the cytotoxic activity against various human cancer cell lines such as prostate (PC-3), breast (MCF-7), CNS (IMR-32), cervix (Hela), and liver (Hep-G2). preliminary cytotoxic screening showed that all the...

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Detalles Bibliográficos
Autores principales: Singh, Balwinder, Sharma, Vishal, Singh, Gagandeep, Kumar, Rakesh, Arora, Saroj, Ishar, Mohan Paul Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207455/
https://www.ncbi.nlm.nih.gov/pubmed/25379292
http://dx.doi.org/10.1155/2013/984329
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author Singh, Balwinder
Sharma, Vishal
Singh, Gagandeep
Kumar, Rakesh
Arora, Saroj
Ishar, Mohan Paul Singh
author_facet Singh, Balwinder
Sharma, Vishal
Singh, Gagandeep
Kumar, Rakesh
Arora, Saroj
Ishar, Mohan Paul Singh
author_sort Singh, Balwinder
collection PubMed
description Novel substituted chromenopyridones (3a–j and 6a–d) were synthesized and evaluated in vitro for the cytotoxic activity against various human cancer cell lines such as prostate (PC-3), breast (MCF-7), CNS (IMR-32), cervix (Hela), and liver (Hep-G2). preliminary cytotoxic screening showed that all the compounds possess a good to moderate inhibitory activity against various cancer cell lines. Particularly, compound 6b bearing allyl moiety displayed a significant cytotoxic potential in comparison to standard drugs.
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spelling pubmed-42074552014-11-06 Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones Singh, Balwinder Sharma, Vishal Singh, Gagandeep Kumar, Rakesh Arora, Saroj Ishar, Mohan Paul Singh Int J Med Chem Research Article Novel substituted chromenopyridones (3a–j and 6a–d) were synthesized and evaluated in vitro for the cytotoxic activity against various human cancer cell lines such as prostate (PC-3), breast (MCF-7), CNS (IMR-32), cervix (Hela), and liver (Hep-G2). preliminary cytotoxic screening showed that all the compounds possess a good to moderate inhibitory activity against various cancer cell lines. Particularly, compound 6b bearing allyl moiety displayed a significant cytotoxic potential in comparison to standard drugs. Hindawi Publishing Corporation 2013 2012-01-08 /pmc/articles/PMC4207455/ /pubmed/25379292 http://dx.doi.org/10.1155/2013/984329 Text en Copyright © 2013 Balwinder Singh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Singh, Balwinder
Sharma, Vishal
Singh, Gagandeep
Kumar, Rakesh
Arora, Saroj
Ishar, Mohan Paul Singh
Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones
title Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones
title_full Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones
title_fullStr Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones
title_full_unstemmed Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones
title_short Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones
title_sort synthesis and in vitro cytotoxic activity of chromenopyridones
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207455/
https://www.ncbi.nlm.nih.gov/pubmed/25379292
http://dx.doi.org/10.1155/2013/984329
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AT kumarrakesh synthesisandinvitrocytotoxicactivityofchromenopyridones
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