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Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles
The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biologic...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207456/ https://www.ncbi.nlm.nih.gov/pubmed/25405032 http://dx.doi.org/10.1155/2013/348948 |
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author | Sharma, Bhawna Verma, Amita Prajapati, Sunil Sharma, Upendra Kumar |
author_facet | Sharma, Bhawna Verma, Amita Prajapati, Sunil Sharma, Upendra Kumar |
author_sort | Sharma, Bhawna |
collection | PubMed |
description | The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. The search for antiepileptic compounds with more selective activity and lower toxicity continues to be an active area of intensive investigation in medicinal chemistry. During the recent years, there has been intense investigation of different classes of thiadiazole compounds, many of which possess extensive pharmacological activities, namely, antimicrobial activity, anticonvulsant, antifungal antidiabetic, anti-inflammatory, antioxidant, and antituberculosis activities, and so forth. The resistance towards available drugs is rapidly becoming a major worldwide problem. The need to design new compounds to deal with this resistance has become one of the most important areas of research today. Thiadiazole is a versatile moiety that exhibits a wide variety of biological activities. Thiadiazole moiety acts as “hydrogen binding domain” and “two-electron donor system.” It also acts as a constrained pharmacophore. On the basis of the reported literature, we study here thiadiazole compounds and their synthetic methods chemistry and anticonvulsant activity. |
format | Online Article Text |
id | pubmed-4207456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42074562014-11-17 Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles Sharma, Bhawna Verma, Amita Prajapati, Sunil Sharma, Upendra Kumar Int J Med Chem Review Article The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. The search for antiepileptic compounds with more selective activity and lower toxicity continues to be an active area of intensive investigation in medicinal chemistry. During the recent years, there has been intense investigation of different classes of thiadiazole compounds, many of which possess extensive pharmacological activities, namely, antimicrobial activity, anticonvulsant, antifungal antidiabetic, anti-inflammatory, antioxidant, and antituberculosis activities, and so forth. The resistance towards available drugs is rapidly becoming a major worldwide problem. The need to design new compounds to deal with this resistance has become one of the most important areas of research today. Thiadiazole is a versatile moiety that exhibits a wide variety of biological activities. Thiadiazole moiety acts as “hydrogen binding domain” and “two-electron donor system.” It also acts as a constrained pharmacophore. On the basis of the reported literature, we study here thiadiazole compounds and their synthetic methods chemistry and anticonvulsant activity. Hindawi Publishing Corporation 2013 2013-04-30 /pmc/articles/PMC4207456/ /pubmed/25405032 http://dx.doi.org/10.1155/2013/348948 Text en Copyright © 2013 Bhawna Sharma et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sharma, Bhawna Verma, Amita Prajapati, Sunil Sharma, Upendra Kumar Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles |
title | Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles |
title_full | Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles |
title_fullStr | Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles |
title_full_unstemmed | Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles |
title_short | Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles |
title_sort | synthetic methods, chemistry, and the anticonvulsant activity of thiadiazoles |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207456/ https://www.ncbi.nlm.nih.gov/pubmed/25405032 http://dx.doi.org/10.1155/2013/348948 |
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