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Investigating the Structure and Dynamics of the PIK3CA Wild-Type and H1047R Oncogenic Mutant

The PIK3CA gene is one of the most frequently mutated oncogenes in human cancers. It encodes p110α, the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Kα), which activates signaling cascades leading to cell proliferation, survival, and cell growth. The most frequent mutation in PIK3CA...

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Detalles Bibliográficos
Autores principales:	Gkeka, Paraskevi, Evangelidis, Thomas, Pavlaki, Maria, Lazani, Vasiliki, Christoforidis, Savvas, Agianian, Bogos, Cournia, Zoe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207468/ https://www.ncbi.nlm.nih.gov/pubmed/25340423 http://dx.doi.org/10.1371/journal.pcbi.1003895

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