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Tumor Xenograft Uptake of a Pyrrole–Imidazole (Py-Im) Polyamide Varies as a Function of Cell Line Grafted

[Image: see text] Subcutaneous xenografts represent a popular approach to evaluate efficacy of prospective molecular therapeutics in vivo. In the present study, the C-14 labeled radioactive pyrrole–imidazole (Py-Im) polyamide 1, targeted to the 5′-WGWWCW-3′ DNA sequence, was evaluated with regard to...

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Detalles Bibliográficos
Autores principales:	Raskatov, Jevgenij A., Szablowski, Jerzy O., Dervan, Peter B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207538/ https://www.ncbi.nlm.nih.gov/pubmed/25238175 http://dx.doi.org/10.1021/jm500964c

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