Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2

[Image: see text] The G protein-coupled chemokine receptors CXCR1 and CXCR2 play key roles in inflammatory diseases and carcinogenesis. In inflammation, they activate and recruit polymorphonuclear cells (PMNs) through binding of the chemokines CXCL1 (CXCR1) and CXCL8 (CXCR1 and CXCR2). Structure–act...

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Detalles Bibliográficos
Autores principales: Maeda, Dean Y., Peck, Angela M., Schuler, Aaron D., Quinn, Mark T., Kirpotina, Liliya N., Wicomb, Winston N., Fan, Guo-Huang, Zebala, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207547/
https://www.ncbi.nlm.nih.gov/pubmed/25254640
http://dx.doi.org/10.1021/jm500827t

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